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| 24-Feb-23 20:00
Estadio IV Centenario
Ref:Flores, Gaad Lm 1:Flores, R Lm 2:Chambi |
| Real Tomayapo
| 0 - 2 | Royal Pari Fútbol Club
15' Amoroso, Joel 23' Bejarano, M 96' Rey, Anderson
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| 25-Feb-23 15:00
Ramón Aguilera
Ref:Silva, S Lm 1:Aramayo Lm 2:Choque |
| Real Santa Cruz
| 0 - 0 | Guabirá
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| 25-Feb-23 17:30
Victor Agustin Ugarte
Ref:Maija Lm 1:Orellana Lm 2:Guisada |
| Nacional Potosi
Prost, Martín 17' Tobar, T 21' Leaños 43' Prost, Martín 50' Mancilla, D 57'
| 5 - 1 | Libertad Gran Mamoré
45' Carrillo, Grovert
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| 25-Feb-23 20:00
Olímpico Patria
Ref:Flores, A Lm 1:Antelo, J Lm 2:Zeballos |
| Independiente Petrolero
Ramírez, Robin 11' Gómez, Rodrigo (1993) 83'
| 2 - 0 | Blooming
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| 26-Feb-23 15:00
Félix Capriles
Ref:Vargas Lm 1:Orellana, R Lm 2:Escalera |
| Universitario de Vinto
Abrego, V 36'
| 1 - 1 | Aurora
49' Blanco, O
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| 26-Feb-23 17:30
Estadio Hernando Siles
Ref:Orozco Lm 1:Arellano Lm 2:Cáceres, W |
| Bolivar
Chávez, LL 32' Fernández, Ronnie 53' Vaca, Ramiro 86' Rodríguez, Patricio (1990) 91'
| 4 - 0 | Oriente Petrolero
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| 26-Feb-23 19:30
Félix Capriles
Ref:Barro Lm 1:Saavedra Lm 2:Antelo |
| Palmaflor
| 0 - 1 | The Strongest
83' Sotomayor, G
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| 27-Feb-23 19:00
Félix Capriles
Ref:Quenta Lm 1:Vallejos, Reluy Lm 2:Blanco, E |
| Jorge Wilstermann
Monteiro, Mizael 21' og Cardozo, Rudy 38'
| 2 - 2 | Vaca Díez
66' Cuadros 73' Ibaguary
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