| | | | | |
| 27-Feb-18 20:00
Estadio Universitario
Atte:37214
Ref: Aguilar
|
 | UANL Tigres 
Valencia, E 49'
Valencia, E 79'
Sosa, Ismael 90'
| 3 - 1 |  CS Herediano
78' Arrieta, J
|
| |
| 27-Feb-18 20:00
BMO Field
Atte:23383
Ref: Santander Aguirre
|
 | Toronto FC 
| 0 - 0 |  Colorado Rapids
|
| |
| 27-Feb-18 22:00
Estadio Caliente
Ref: Escobar, M
|
 | Club Tijuana
García Collazo 3'
| 1 - 1 |  CD Motagua
88' Martínez, W
|
| |
| 28-Feb-18 20:00
Estadio Chivas
Ref: Fischer, D
|
 | Chivas Guadalajara
Alanís, O 45' 
Cisneros, Carlos 53'
Macías, José (1999) 56'
Pulido, Alan 74'
Mayorga, M 78'
| 5 - 0 |  Cibao FC
|
| |
| 28-Feb-18 20:00
Toyota Stadium
Ref: Rodríguez, H
|
 | FC Dallas
Urruti 32'
Díaz, Mauro 50' 
Colmán, Cristian 90'
| 3 - 2 |  Tauro FC
15' Aguilar
44' González, Jesús (1996)
|
| |
| 28-Feb-18 22:00
Estadio Azteca
Ref: Moncada
|
 | América
Quintero 1'
| 1 - 1 | Deportivo Saprissa
53' Torres, Mariano
|
| |
| 01-Mar-18 20:00
Red Bull Arena
Atte:11677
Ref: Montero, R
|
 | New York Red Bulls
Wright-Phillips, B 54'
Davis, Sean (1993) 64'
| 2 - 0 | CD Olimpia
|
| |
| 01-Mar-18 22:00
Lumen Field
Atte:35549
Ref: Lopez
|
 | Seattle Sounders
Bruin 48'
Lodeiro 69'
Marshall, C 81'
Eikrem 83'
| 4 - 0 | Santa Tecla
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