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| 10-Sep-21 19:40
Jaraguay
Ref:Herrera, M
Lm 1:León, A
Lm 2:Motta
|
 | Jaguares de Córdoba
| 0 - 1 | Independiente Medellin
78' Castro, LF
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| 11-Sep-21 14:00
Estadio de la Independencia
Ref:Mosquera, W
Lm 1:Escobar
Lm 2:Castro, JE
|
 | Patriotas
| 0 - 0 | Envigado
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| 11-Sep-21 16:00
Palogrande
Atte:2000
Ref:Ruiz, D
Lm 1:Ortiz, R
Lm 2:Padilla, RC
|
 | Once Caldas
Pérez, JD 40'
Pérez, JD 96' 
| 2 - 3 | Aguilas Doradas
23' Miranda, JF
45' Marrugo
47' Angulo, Álvaro
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| 11-Sep-21 18:05
Estadio Deportivo Cali
Ref:Roldán
Lm 1:Ruiz, D
Lm 2:Padilla, G
|
 | Deportivo Cali
Rodríguez, Angelo 23' 
Rodríguez, Angelo 23' 
| 0 - 1 | América de Cali
17' Batalla, E
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| |
| 11-Sep-21 20:10
El Campín
Ref:Tabares
Lm 1:Gallego
Lm 2:Wilches
|
 | Santa Fe
Dinolis 81'
| 1 - 1 | Alianza Petrolera
83' Riquett
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| 12-Sep-21 14:00
Alfonso López
Atte:2500
Ref:Ospina, A
Lm 1:Aguilar, J
Lm 2:Patiño
|
 | Atletico Bucaramanga
Palacio, Duban 12'
Meléndez, A 69'
Acosta, David 79' 
| 3 - 4 | Millonarios
45' Ruiz, Daniel
45' Uribe, F
63' Ruiz, Daniel
65' Uribe, F
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| 12-Sep-21 16:00
Hernán Ramírez Villegas
Ref:Betancur
Lm 1:Vela
Lm 2:Flechas
|
 | Deportivo Pereira
De la Rosa, W 35'
| 1 - 1 | Junior
85' González, Luis (1990)
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| 12-Sep-21 18:05
Atanasio Girardot
Ref:Ararat
Lm 1:Guzmán, A
Lm 2:Guerra, HF
|
 | Atletico Nacional
Perlaza, B 48'
Duque, J 51'
| 2 - 0 | La Equidad
|
| |
| 13-Sep-21 18:00
Centenario
Ref:Matorel
Lm 1:Roldán
Lm 2:Calderón, H
|
 | Deportes Quindío
Pino, D 45' 
Balanta, Jhon 76'
| 1 - 2 | Deportivo Pasto
45' Duarte, Mauricio
 66' Rendón, K
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| 13-Sep-21 20:00
Guillermo Plazas Alcid
Ref:Ortega, C
Lm 1:Navarro
Lm 2:Piedrahita
|
 | Atletico Huila
Moreno, Brayan 4'
Arias, D 69'
| 1 - 2 | Deportes Tolima
18' Mosquera, S
71' Mosquera, S
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