| | | | | |
| 24-May-22 19:15
Parque Central
Ref: Roldán
Lm 1: Guzmán, A
Lm 2: Navarro
|
 | Nacional 
Trezza 9'
Cándido 31'
Fagúndez, Franco (2000) 84' 
Cleiton Schwengber 84'  og
| 3 - 0 |  Red Bull Bragantino
|
| |
| 24-May-22 19:15
Jose Amalfitani
Ref: Gamboa, N
Lm 1: Rocha
Lm 2: Serrano
|
 | Velez Sarsfield 
Janson 21'
Janson 43'
Pratto 73'
Osorio, Abiel 83'
| 4 - 0 | Estudiantes de La Plata
|
| |
| 24-May-22 20:30
San Carlos de Apoquindo
Ref: Vargas
Lm 1: Antelo
Lm 2: Saavedra
|
 | Universidad Católica
| 0 - 1 | Talleres de Cordoba
61' Esquivel, M
|
| |
| 24-May-22 20:30
George Capwell
Ref: Ortega, C
Lm 1: Vela
Lm 2: Gallego
|
 | Emelec 
Cabeza 16'
Cabeza 35'
Rodríguez, Sebastián (1992) 38'
Cevallos, Jose (1995) 45' 
Rojas, Joao (1997) 54'
Quiroga, Mauro 75'
Rodríguez, Sebastián (1992) 77'
| 7 - 0 | Independiente Petrolero
|
| |
| 24-May-22 21:30
Estádio do Maracanã
Ref: Herrera
Lm 1: Lopez, C
Lm 2: Díaz, Jackson
|
 | Flamengo
Isla 30'
Pedro, AdS 74'
| 2 - 1 |  Sporting Cristal
85' Gonzales, Christofer
|
| |
| 24-May-22 21:30
Allianz Parque
Ref: Ortega, K
Lm 1: Sánchez, J
Lm 2: Orué
|
 | Palmeiras
Gustavo Scarpa 15'
Gustavo Scarpa 22' 
Rony, dSB 57'
Gustavo Scarpa 68'
| 4 - 1 | Deportivo Táchira
48' Gutiérrez, Jean
|
| |
| 25-May-22 18:00
Monumental David Arellano
Ref: Ostojich
Lm 1: Barreiro
Lm 2: Llarena
|
 | Colo Colo
Ceballos, B 45' og
Ceballos, B 64' og
Gil, Leonardo 80'
| 3 - 4 | Fortaleza
3' Romero, Silvio
25' Moisés, Vieira
 45' Ronald, dSL
54' Moisés, Vieira
61' Yago Pikachu
|
| |
| 25-May-22 19:00
Monumental
Ref: Ospina, A
Lm 1: Ruiz, D
Lm 2: Roldán
|
 | River Plate
Álvarez, Julián 15'
Álvarez, Julián 18'
Álvarez, Julián 41'
Simón, S 53'
Álvarez, Julián 54'
Álvarez, Julián 57'
Gómez, Elías 79'
Álvarez, Julián 83'
| 8 - 1 | Alianza Lima
89' Lavandeira, P
|
| |
| 25-May-22 19:00
Estadio Banco Guayaquil
Ref: González, L
Lm 1: Taran
Lm 2: Soppi
|
 | Independiente del Valle
Sornoza 17'
Gaibor 43'
Chavez, Jhoanner 74'
| 3 - 0 | América-MG
|
| |
| 25-May-22 20:00
Estadio General Pablo Rojas
Ref: Claus
Lm 1: Boschilia
Lm 2: da Silva Alves
|
 | Cerro Porteño 
Aquino, C 95'
| 0 - 1 | Olimpia
10' Cardozo, Fernando
95' Olveira
|
| |
| 25-May-22 21:00
Mineirão
Ref: Loustau, P
Lm 1: Rodríguez, F
Lm 2: Savorani
|
 | Atlético Mineiro
Eduardo Sasha 88'
| 1 - 2 | Deportes Tolima
55' Rangel, M
92' Lucumí
|
| |
| 25-May-22 21:00
Estadio Campeón del Siglo
Ref: Daronco
Lm 1: Gil
Lm 2: Rocha de Matos
|
 | Peñarol
Ceppelini 48'
Menosse, H 97'
| 2 - 1 | Colón de Santa Fe
32' Farías, Facundo
63'
|
| |
| 26-May-22 18:00
Estadio Defensores del Chaco
Ref: Tello
Lm 1: Belatti
Lm 2: Bonfá
|
 | Libertad
Melgarejo 25'
Mendieta, WG 55'
Santa Cruz 70'
Mendieta, WG 90'
| 4 - 1 | The Strongest
41' Ursino
|
| |
| 26-May-22 19:00
Arena da Baixada
Ref: Lamolina, N
Lm 1: Navarro
Lm 2: González, P
|
 | Atlético Paranaense
Pablo, Felipe (1992) 19'
Pablo, Felipe (1992) 22'
Christian, Alves 45'
Christian, Alves 71'
Pedro Rocha, N 75'
Anderson, SdP 90'
| 5 - 1 | Caracas
58' Rivero, Carlos
|
| |
| 26-May-22 21:00
Bombonera
Ref: Maza
Lm 1: Schiemann
Lm 2: Ríos, C
|
 | Boca Juniors
Varela, Alan 54'
| 1 - 0 | Deportivo Cali
|
| |
| 26-May-22 21:00
Arena Corinthians
Ref: Argote
Lm 1: Chacón
Lm 2: García, A
|
 | Corinthians
Adson, FS 19'
| 1 - 1 | Always Ready
44' Borja, Jonathan
|
| |
|  |
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