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| 04-May-21 18:15
Olímpico Ciudad Universitaria Atte:1
Ref: Espinoza, F Lm 1: Navarro Lm 2: Germanotta |
| Metropolitanos
Flores, RD 14' Moreno, Johan 51' Pavone, T 65'
| 3 - 2 | Aucas
67' Ordóñez, R 69' Carrera, Alex
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| 04-May-21 19:15
Governador Roberto Santos Atte:1
Ref: Tobar Lm 1: Schiemann Lm 2: Aguiar, J |
| Bahia
Thaciano 57' Júnior, dOAJ 66' Luiz Otávio, dSS 82' Gilberto, OS 86'
| 2 - 2 | Independiente
43' Herrera, Jonathan (1991) 51' Velasco, Alan 86' Sosa, Seba (1986)
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| 04-May-21 19:30
Estadio Nacional de Lima Atte:1
Ref: Betancur Lm 1: Navarro Lm 2: Fuentes, D |
| FBC Melgar
Bordacahar 50'
| 1 - 0 | Atlético Paranaense
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| 04-May-21 20:30
El Teniente Atte:1
Ref: Carrillo Lm 1: Bossio Lm 2: Lopez, R |
| Palestino
| 0 - 1 | Newells Old Boys
92' Rodríguez, Alexis (1996)
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| 05-May-21 18:15
Sausalito Atte:1
Ref: Claus Lm 1: Manis Lm 2: Pires |
| Huachipato
Altamirano, J 33'
| 1 - 1 | Rosario Central
67' Zabala, D
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| 05-May-21 18:15
Estadio Hernando Siles Atte:1
Ref: Fedorczuk Lm 1: Fernández, S Lm 2: Trinidad |
| Bolivar
| 0 - 0 | Ceará
61' Jael 61' Jael
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| 05-May-21 19:15
Parque Alfredo Víctor Viera Atte:1
Ref: Vera, M Lm 1: Romero Lm 2: Guerrero |
| Montevideo City Torque
Rak, J 11' Rak, J 11' Scotto, S 34' Del Prete, G 71' Guerrero, Sebastián (2000) 91' Del Prete, G 93'
| 4 - 0 | Guabirá
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| 05-May-21 21:30
Nabi Abi Chedid Atte:1
Ref: Gamboa, N Lm 1: Ríos, C Lm 2: Orellana |
| Red Bull Bragantino
| 0 - 1 | Talleres de Cordoba
93' Valoyes, DL
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| 06-May-21 18:15
Estadio Defensores del Chaco Atte:1
Ref: Vargas Lm 1: Antelo Lm 2: Saavedra |
| Libertad
Barboza, Alexander 88' Bareiro, A 92'
| 1 - 2 | Atlético Goianiense
40' Zé Roberto, dAF 86' Arnaldo
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| 06-May-21 19:15
Julio H. Grondona Atte:1
Ref: Hermosilla Lm 1: Serrano Lm 2: Urrutia |
| Arsenal Sarandi
Albertengo, L 1' Candia, JM 84' Candia, JM 87'
| 3 - 0 | Jorge Wilstermann
|
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| 06-May-21 19:15
Arena do Grêmio Atte:1
Ref: Guerrero, G Lm 1: Lescano Lm 2: Aguiar, J |
| Grêmio Porto Alegre
Luiz Fernando, Moraes 3' Luiz Fernando, Moraes 18' Diego Souza 21' Ferreira, Aldemir 22' Ferreira, Aldemir 24' Hernández, Arq 28' og Maicon, Thiago 64' Churín 77'
| 8 - 0 | Aragua
|
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| 06-May-21 19:30
Estadio Nacional de Lima Atte:1
Ref: Ospina, A Lm 1: Navarro Lm 2: Fuentes, D |
| Sport Huancayo
| 0 - 3 | Corinthians
5' Luan, Vieira 31' Cauê, (2002) 76' Luan, Vieira
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| 06-May-21 21:30
Nuevo Gasometro Atte:1
Ref: Wilton Sampaio Lm 1: Gil Lm 2: Boschilia |
| San Lorenzo
Troyansky, Franco 31'
| 1 - 1 | 12 de Octubre
45' Núñez, JA
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| 06-May-21 21:30
Estadio Campeón del Siglo Atte:1
Ref: Orbe Lm 1: Romero Lm 2: Guerrero |
| Peñarol
Kagelmacher 22' Torres, Facundo (2000) 80' Canobbio, A 89'
| 3 - 0 | River Plate de Asunción
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| 06-May-21 22:00
Estadio Defensores del Chaco Atte:1
Ref: López, D Lm 1: Cardozo Lm 2: Aquino |
| La Equidad
| 0 - 1 | Lanus
27' Vera, Lucas
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| 07-May-21 19:00
Monumental Atte:1
Ref: Haro, D Lm 1: Carrera, C Lm 2: Raez |
| Deportes Tolima
Mosquera, S 22'
| 1 - 1 | Emelec
41' Zapata, Alexis
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