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| 05-Jul-22 19:15
15 de Abril
Ref: Maza
Lm 1: Molina Bravo
Lm 2: Urrutia
|
 | Union Santa Fe 
Brítez, E 69' 
| 1 - 2 |  Nacional
77' Ramírez, Ignacio
83' Rodríguez, JL (1997)
|
| |
| 05-Jul-22 21:30
Beira-Rio
Atte:37695
Ref: Herrera
Lm 1: Chade
Lm 2: Del Yesso
|
 | Internacional 
Alan Patrick 28'
Edenilson 32'
Alemão, Z 59'
Pedro Henrique, K 74'
| 4 - 1 | Colo Colo
 15' Costa, G
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| |
| 06-Jul-22 19:15
Placido Aderaldo Castelo
Ref: López, D
Lm 1: Cuevas, J
Lm 2: Onieva
|
 | Ceará
Richardson 23'
Victor Luís 26'
Mendoza, John 31' 
Mendoza, John 31' 
Lima, Vinicius 51'
| 3 - 0 |  The Strongest
|
| |
| 06-Jul-22 19:30
Estadio Monumental de la UNSA
Ref: Tello
Lm 1: Bonfá
Lm 2: Navarro
|
 | FBC Melgar 
Cuesta, B 57'
Cuesta, B 72'
| 2 - 1 |  Deportivo Cali
55' Mera, G
96' Mosquera, Harold
|
| |
| 06-Jul-22 21:30
Vila Belmiro
Ref: Ortega, K
Lm 1: Orué
Lm 2: Sánchez, J
|
 | Santos
Marcos Leonardo 69'
Ricardo Goulart 98' 
Sandry 98' 
Sánchez, Carlos (1984) 98'
Lucas Barbosa, H 98'
| 1 - 1
(2) : (4) |  Deportivo Táchira
27' Uribe, A
98' Farías, Edder
98' Simisterra
98' Arace
98' Fernández, Marlon
|
| |
| 07-Jul-22 19:15
Ciudad de Lanus
Ref: Garay
Lm 1: Retamal
Lm 2: Cisternas
|
 | Lanus
| 0 - 0 |  Independiente del Valle
|
| |
| 07-Jul-22 21:30
Morumbi
Atte:47097
Ref: Herrera
Lm 1: Lopez, C
Lm 2: Torrealba, L
|
 | São Paulo
Luciano, Neves 14'
Éder, Citadin 45'
João Moreira, S 59'
Rodriguinho, Mendonça 81'
| 4 - 1 | Universidad Católica
45' Valencia, D
88' Fuenzalida
|
| |
| 07-Jul-22 21:30
Serra Dourada
Atte:14419
Ref: Roldán
Lm 1: Guzmán, A
Lm 2: Vela
|
 | Atlético Goianiense
Churín 4'
Airton, Moisés 7'
Wellington Rato 95'
Baralhas 95'
Shaylon 95'
Rickson 95'
Marlon Freitas 95'
| 2 - 0
(5) : (3) | Olimpia
95' Silva, Alejandro
95' Quintana, H
95' Ortiz, R
95' Cardozo, Fernando
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