| | | | | |
| 27-Oct-21 18:00
Gillette Stadium
Ref:Rivas, V
|
 | New England Revolution
Buchanan, T 74'
| 1 - 0 | Colorado Rapids
|
| |
| 27-Oct-21 18:30
Mercedes-Benz Stadium
Ref:Gonzalez Jr
|
 | Atlanta United FC
Luiz Araújo 59'
Martinez, Josef 73'
| 2 - 1 | Inter Miami CF
 31' Morgan, L
 32' Higuaín
|
| |
| 27-Oct-21 18:30
Lower.com Field
Ref:Dickerson
|
 | Columbus Crew
Berry, M 20'
Etienne, D 31'
Zelarayán 61'
| 3 - 2 | Orlando City
48' Pereyra, M
52' Dike, D
90' Jansson, Robin
|
| |
| 27-Oct-21 18:30
West End Stadium
Atte:20581
Ref:Touchan
|
 | FC Cincinnati
Romney, Dave 6'  og
Brenner, SdS 17'
Castillo, Edgar 23'
Brenner, SdS 25' 
Vázquez, B 32'
| 3 - 6 | Nashville SC
28' Zimmerman, W
45' Leal, Randall
71' Sapong
76' Leal, Randall
80' Loba
90' Sapong
|
| |
| 27-Oct-21 18:30
Yankee Stadium
Ref:Bazakos, F
|
 | New York City FC
Castellanos, Taty 51'
| 1 - 0 | Chicago Fire
|
| |
| 27-Oct-21 18:30
BMO Field
Ref: Petrescu
|
 | Toronto FC
Altidore 66'
Elliott, J 70' og
| 2 - 2 | Philadelphia Union
1' Bedoya, A
77' Sergio Santos, (1994)
|
| |
| 27-Oct-21 18:30
Audi Field
Ref:Vazquez
|
 | D.C. United
Paredes, K 9'
| 1 - 0 | New York Red Bulls
|
| |
| 27-Oct-21 19:00
Toyota Stadium
Ref:Elfath
|
 | FC Dallas
Hedges 20'
| 1 - 2 | Real Salt Lake
80' Kreilach
90' Rusnák
|
| |
| 27-Oct-21 19:30
Children's Mercy Park
Ref: Kelly, A
|
 | Sporting Kansas City
Russell, Johnny 40'
Russell, Johnny 82'
| 2 - 0 | LA Galaxy
|
| |
| 27-Oct-21 21:00
BC Place
Ref:Saghafi
|
 | Vancouver Whitecaps
Boxall 45' og
White, Brian 63'
| 2 - 1 | Minnesota United FC
90' Adi, F
|
| |
|  |
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