| | | | | |
| 17-Sep-22 15:30
Mercedes-Benz Stadium
Atte:42521
Ref:Gonzalez Jr
|
 | Atlanta United FC
| 0 - 0 | Philadelphia Union
|
| |
| 17-Sep-22 19:00
BC Place
Atte:19722
Ref:Touchan
|
 | Vancouver Whitecaps 
Vite, P 29'
Gressel 37'
| 2 - 1 | Seattle Sounders
 89' Bruin
|
| |
| 17-Sep-22 19:00
Soldier Field
Atte:21450
Ref:Penso, T
|
 | Chicago Fire
Pineda, Mauricio (1997) 3'
Durán, JJ 30'
| 2 - 3 | Charlotte FC
68' Świderski
76' Nuno Santos, (1999)
96' Świderski
|
| |
| 17-Sep-22 19:30
Gillette Stadium
Atte:35455
Ref:Mendoza, R
|
 | New England Revolution
| 0 - 1 | CF Montréal
72' Johnston, A
|
| |
| 17-Sep-22 19:30
Inter&Co Stadium
Atte:17189
Ref:Saghafi
|
 | Orlando City
Torres, Facundo (2000) 9'
Kara, E 22'
MacNaughton 47'  og
Akindele 84'
| 4 - 0 | Toronto FC
|
| |
| 17-Sep-22 19:30
Children's Mercy Park
Atte:19680
Ref:de Oliveira, M
|
 | Sporting Kansas City
Boxall 31' og
Thommy 41'
Agade 45'
Agade 81'
| 4 - 1 | Minnesota United FC
57' García, Mender
|
| |
| 17-Sep-22 19:30
America First Field
Atte:20222
Ref:Penso, C
|
 | Real Salt Lake
Chang, M 35'
| 1 - 2 | FC Cincinnati
44' Brenner, SdS
76' Brenner, SdS
|
| |
| 17-Sep-22 19:30
Dignity Health Sports Park
Atte:20325
Ref:Dickerson
|
 | LA Galaxy
Brugman 22'
Edwards, Raheem 28'
Hernández, Javier (1988) 31'
Brugman 52'
| 4 - 1 | Colorado Rapids
91' Nicholson, Sam
|
| |
| 17-Sep-22 20:00
Yankee Stadium
Atte:30151
Ref:Chapman
|
 | New York City FC
Callens 1'
Rodríguez, Santiago (2000) 23'
| 2 - 0 | New York Red Bulls
|
| |
| 17-Sep-22 20:00
PayPal Park
Atte:12355
Ref: Fischer, D
|
 | San Jose Earthquakes
Ebobisse, J 24' 
| 1 - 1 | FC Dallas
16' Obrian
|
| |
| 17-Sep-22 20:00
Austin FC Stadium
Atte:20738
Ref:Szpala
|
 | Austin FC
Driussi 61'
| 1 - 1 | Nashville SC
56' Mukhtar
|
| |
| 18-Sep-22 13:00
Lower.com Field
Atte:20421
Ref:Rivas, V
|
 | Columbus Crew
Molino 36'
| 1 - 1 | Portland Timbers
95' Moreno, Santiago
|
| |
| 18-Sep-22 17:00
Audi Field
Atte:14284
Ref:Elfath
|
 | D.C. United
Benteke 22'
Fountas 57'
| 2 - 3 | Inter Miami CF
39' Campana
53' Campana
94' Higuaín
|
| |
| 18-Sep-22 19:30
BMO Stadium
Atte:22131
Ref:Stott, K
|
 | Los Angeles FC
Vela 8'
Vela 45'
Hollingshead 52'
| 3 - 1 | Houston Dynamo
24' Baird, C
|
| |
|  |
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