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| 16-Apr-22 12:30
PayPal Park
Atte:10394
Ref:Ford, T
|
 | San Jose Earthquakes
Ebobisse, J 52' 
Ebobisse, J 72'
| 2 - 2 | Nashville SC
38' Mukhtar
63' Mukhtar
|
| |
| 16-Apr-22 15:00
Stade Saputo
Atte:12042
Ref:Saghafi
|
 | CF Montréal 
Mihailovic 1'
Quioto 47'
| 2 - 1 | Vancouver Whitecaps
65' White, Brian
|
| |
| 16-Apr-22 17:00
Shell Energy Stadium
Atte:13650
Ref:Mendoza, R
|
 | Houston Dynamo
| 0 - 0 | Portland Timbers
|
| |
| 16-Apr-22 18:00
Mercedes-Benz Stadium
Atte:42948
Ref:Vazquez
|
 | Atlanta United FC
Moreno, Marcelino 63' 
| 0 - 0 | FC Cincinnati
|
| |
| 16-Apr-22 19:00
Red Bull Arena
Atte:14456
Ref:Bazakos, F
|
 | New York Red Bulls
| 0 - 0 | FC Dallas
|
| |
| 16-Apr-22 19:00
Soldier Field
Atte:30282
Ref:Unkel, T
|
 | Chicago Fire
| 0 - 0 | LA Galaxy
|
| |
| 16-Apr-22 19:00
Allianz Field
Ref:Penso, C
|
 | Minnesota United FC
Dibassy 42' 
Lod 77'
Danladi 79'
| 3 - 1 | Colorado Rapids
45' Rubio, D
|
| |
| 16-Apr-22 19:00
Lumen Field
Atte:32126
Ref:Dickerson
|
 | Seattle Sounders
| 0 - 1 | Inter Miami CF
41' Robinson, Robbie
|
| |
| 16-Apr-22 19:30
Lower.com Field
Atte:18030
Ref: Fischer, D
|
 | Columbus Crew
| 0 - 2 | Orlando City
37' Schlegel, R
51' Kara, E
|
| |
| 16-Apr-22 19:30
BMO Field
Atte:20809
Ref:Chilowicz
|
 | Toronto FC
Jesús Jiménez, (1993fw) 39'
Pozuelo 51'
| 2 - 1 | Philadelphia Union
34' Carranza, Julián
|
| |
| 16-Apr-22 19:30
Gillette Stadium
Atte:15344
Ref: Lauzière
|
 | New England Revolution
Buksa 8'
Polster, M 72'
| 2 - 1 | Charlotte FC
85' Ortíz, Cristian (1992)
|
| |
| 16-Apr-22 20:00
Audi Field
Atte:16840
Ref:Penso, T
|
 | D.C. United
Kamara, O 26'
Kamara, O 40'
| 2 - 3 | Austin FC
80' Hoesen
85' Driussi
90' Gabrielsen, R
|
| |
| 17-Apr-22 13:00
Yankee Stadium
Atte:14513
Ref:Elfath
|
 | New York City FC
Castellanos, Taty 9'
Thiago Andrade 15'
Castellanos, Taty 40' 
Thiago Andrade 55'
Castellanos, Taty 57'
Castellanos, Taty 80'
| 6 - 0 | Real Salt Lake
|
| |
| 17-Apr-22 13:00
BMO Stadium
Atte:22097
Ref:Villarreal
|
 | Los Angeles FC
Arango, C 44'
Tajouri 70'
Cifuentes, JA 78'
| 3 - 1 | Sporting Kansas City
 og 38' Palacios, Diego
|
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