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| 16-May-23 18:00
Parque del Guairá
Ref:Díaz de Vivar
Lm 1:Britos
Lm 2:Fernández, N
|
 | Guaireña FC
| 0 - 2 | Libertad
 3' Gómez, Diego (2003)
52' Villalba, H
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| |
| 16-May-23 20:30
Manuel Ferreira
Ref:Méndez, J
Lm 1:Cuevas, J
Lm 2:Gaona
|
 | Olimpia
Bruera, F 12'
| 1 - 1 | General Caballero JLM
74' González, Clementino
|
| |
| 17-May-23 18:00
Estadio Defensores del Chaco
Ref:López, D
Lm 1:Cardozo
Lm 2:Miranda, G
|
 | Sportivo Luqueño
Castro, Matías (1991dec) 65' 
| 1 - 1 | Cerro Porteño
42' Espínola, Alberto
|
| |
| 17-May-23 20:30
Luis Alfonso Giagni
Ref:Benitez, J
Lm 1:Cañete
Lm 2:Saldivar, M
|
 | Tacuary
Martínez, Luis (2003) 58'
| 1 - 3 | Guaraní
38' Fariña
45' Barceló
90' Borja, E
|
| |
| 18-May-23 18:00
Martín Torres
Ref:Benitez, C
Lm 1:Candia
Lm 2:Medina, H
|
 | Trinidense
Álvarez, Alex 32'
Maná 86'
| 2 - 0 | Sportivo Ameliano
|
| |
| 18-May-23 20:30
Estadio Defensores del Chaco
Ref:Ojeda, D
Lm 1:Martínez, H
Lm 2:Sosa, C
|
 | Nacional
Ocampos, C 53' 
| 0 - 0 | Resistencia
 53' Rhuan
|
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