| | | | | |
| 10-Mar-23 19:00
Estadio Tigo La Huerta
Ref:Benitez, J
Lm 1:Saldivar, M
Lm 2:Martínez, H
|
 | Libertad
Melgarejo 47'
Villalba, H 92'
| 2 - 0 | Guaireña FC
|
| |
| 12-Mar-23 18:00
Antonio Aranda Encina
Ref:Quintana
Lm 1:Onieva
Lm 2:Sosa, C
|
 | General Caballero JLM
González, Clementino 22' 
| 1 - 2 | Olimpia
 18' González, Derlis (1994)
23' Cardozo, Fernando
|
| |
| 12-Mar-23 20:30
Luis Alfonso Giagni
Ref:Ojeda, D
Lm 1:Cañete
Lm 2:Weiler
|
 | Resistencia
| 0 - 1 | Nacional
55' Caballero, Gustavo
|
| |
| 13-Mar-23 18:00
Luis Alfonso Giagni
Ref:López, J
Lm 1:Candia
Lm 2:Fernández, N
|
 | Sportivo Ameliano
Doldán, J 8' 
Ortiz, Luis (2000) 55'
Torales, S 92'
| 2 - 1 | Trinidense
 8' Gavilán, P
78' Maná
|
| |
| 13-Mar-23 19:00
Rogelio Livieres
Ref:López, D
Lm 1:Cardozo
Lm 2:Aranda
|
 | Guaraní
Cáceres, Marcos 29'
| 1 - 0 | Tacuary
|
| |
| 13-Mar-23 20:30
Estadio General Pablo Rojas
Ref:Benitez, C
Lm 1:Britos
Lm 2:Medina, H
|
 | Cerro Porteño
Carrascal, R 81'
Bobadilla, D 89'
Samudio, B 91'
| 3 - 3 | Sportivo Luqueño
16' Pérez, Marcelo (2001)
61' Charpentier
99' Aguilar, Pablo (1987)
|
| |
|  |
|