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| 15-Sep-23 17:00
Parque del Guairá
Ref:Romero, B Lm 1:Cañete Lm 2:Candia |
| Guaireña FC
Verdún 45' Borja, E 87'
| 2 - 0 | Trinidense
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| 15-Sep-23 19:30
Arsenio Erico
Ref:Méndez, J Lm 1:Saldivar, M Lm 2:Fernández, N |
| Nacional
Aguilar, GÁ 68' Espínola, Héctor 93' Núñez, Claudio 95'
| 2 - 1 | Sportivo Luqueño
51' Fernández, Diego (2002) 93' Castro, Matías (1991dec)
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| 16-Sep-23 16:30
Luis Alfonso Giagni
Ref:López, D Lm 1:Onieva Lm 2:Gaona |
| Tacuary
| 0 - 4 | Libertad
48' Cardozo, O 63' Merlini, B 67' Villalba, H 93' Barboza, Alexander
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| 16-Sep-23 19:00
Manuel Ferreira
Ref:Díaz de Vivar Lm 1:Britos Lm 2:Weiler |
| Olimpia
Silva, Alejandro 79' Romero, Manuel 81' Montenegro, B 94'
| 3 - 1 | General Caballero JLM
7' Machuca, M
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| 17-Sep-23 16:30
Luis Alfonso Giagni
Ref:Quiñónez Lm 1:Cuevas, J Lm 2:Villagra |
| Sportivo Ameliano
Vera, Elvio 52'
| 1 - 2 | Resistencia
71' Moreira, J 79' Díaz, Estifen
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| 17-Sep-23 19:00
Rogelio Livieres
Ref:Benitez, J Lm 1:Cardozo Lm 2:Medina, H |
| Guaraní
Camacho, N 55'
| 1 - 0 | Cerro Porteño
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