| | | | | |
| 12-Mar-22 17:00
Segra Field
Ref:Matto
|
 | Loudoun United FC
Smith, Kimarni 43'
Hopkins, J 79' 
| 1 - 0 | Indy Eleven
|
| |
| 12-Mar-22 17:00
Sand Creek Stadium
Ref:Alael-din Badawi
|
 | Colorado Springs Switchbacks
Ngalina 37'
Johnson, M 51'
| 2 - 1 | Orange County SC
82' Iloski, M
|
| |
| 12-Mar-22 17:30
H-E-B Park
Ref:Stevis
|
 | Rio Grande Valley FC Toros
López, FM 34'
| 1 - 0 | Oakland Roots SC
|
| |
| 12-Mar-22 18:00
AutoZone Park
Ref:Broadley
|
 | Memphis 901 FC
| 0 - 3 | Pittsburgh Riverhounds
45' Kelly, Dane
64' Cicerone
76' Dikwa
|
| |
| 12-Mar-22 18:00
Riccardo Silva Stadium
Ref:Giusti
|
 | Miami FC
Pérez, Jsh 11'
Segbers 73'
| 2 - 0 | New York Red Bulls II
|
| |
| 12-Mar-22 18:00
Blackbaud Stadium
Ref:Encarnación, J
|
 | Charleston Battery
Williams, Augustine 10'
| 1 - 0 | FC Tulsa
|
| |
| 12-Mar-22 18:30
Lynn Family Stadium
Ref:Rivas, M
|
 | Louisville City
Harris, Wilson 70'
| 1 - 0 | Atlanta United 2
|
| |
| 12-Mar-22 19:30
Peoria Sports Complex
Ref:Radosav
|
 | Phoenix Rising FC
Madrid Quezada 2'
Hurst, Greg 27'
Rodriguez, Arturo 34'
Quinn, Aodhan 40'
| 4 - 2 | Monterey Bay FC
77' Conneh
87' Rebollar
|
| |
| 12-Mar-22 19:30
Toyota Field
Ref:Osmanovic
|
 | San Antonio FC
Garcia, Fabien 68'
| 1 - 0 | Detroit City FC
|
| |
| 12-Mar-22 20:00
Torero Stadium
Ref:Arreguin
|
 | San Diego Loyal SC
Amang 78'
Neal, Jalen 97'  og
| 2 - 1 | LA Galaxy II
84' Judd, P
|
| |
| 12-Mar-22 20:00
Papa Murphy s Park
Ref:Garcia, E
|
 | Sacramento Republic
López, Rodrigo (1988) 45' 
Martínez, Douglas (1997) 85'
Keko 91'
| 3 - 1 | El Paso Locomotive FC
27' Sonupe
|
| |
| 13-Mar-22 15:00
BBVA Field
Ref:Thompson, M
|
 | Birmingham Legion FC
Marlon, dSP 86'
| 1 - 1 | Tampa Bay Rowdies
34' Cochran, Carl
|
| |
| 13-Mar-22 16:00
Isotopes Park
Ref:Flores, G
|
 | New Mexico United
Swartz 37'
Brett, N 49'
| 2 - 0 | Las Vegas Lights FC
|
| |
|  |
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