| Lineups found Starting lineup changes since last game |
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| July 2021 |
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| Coach Smith, D since 10-Oct-18 |
| August 2021 |
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 07-Aug to 13-Aug Emi Buendía Hip Injury |
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| 15-Aug to 10-Sep Traore, B Thigh Injury |
| M.2 | 24-Aug | away | Barrow | | 0-6 | 4-2-3-1 | |
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| 25-Aug to 10-Sep Ramsey, J Covid-19 |
| September 2021 |
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| Coach Danks since 01-Sep-21 |
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| 28-Aug to 10-Sep Konsa, E Knee Injury |
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| 28-Aug to 21-Sep Chukwuemeka, Carney Groin Injury |
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| 29-Aug to 22-Sep Philogene-Bidace Ankle Injury |
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 09-Sep to 17-Sep Emi Buendía Quarantine Rgulations |
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| 18-Sep to 24-Sep Targett Abductor Injury |
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| 22-Sep to 15-Oct Sanson Hamstring Strain |
| M.3 | 22-Sep | away | Chelsea | | 1-1 | 4-2-3-1 | In:Cash, Young, Sanson, Traore, E Buendía, Out:Guilbert, Targett, Hourihane, Phil'ce, Chuk'ka, |
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| October 2021 |
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| 24-Sep to 25-Sep Tuanzebe Unable to Face Parent Club |
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| 26-Sep to 30-Oct Chukwuemeka, Carney Muscle Injury |
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| 04-Oct to 31-Oct Traore, B Thigh Injury |
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| 16-Oct to 21-Oct Cash, Matty Thigh Injury |
| December 2021 |
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| Coach Gerrard since 11-Nov-21 |
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| Coach Beale since 11-Nov-21 |
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| Coach McAllister since 11-Nov-21 |
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| 13-Dec to 08-Apr Nakamba Knee Injury |
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| 13-Dec to 29-Dec Traore, B Thigh Injury |
| January 2022 |
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| 27-Dec to 29-Dec Steer, J Illness |
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| 27-Dec to 29-Dec El-Ghazi Illness |
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| 27-Dec to 29-Dec Sanson Illness |
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| 01-Jan to 03-Jan Young, A Ankle Injury |
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| 14-Jan to 16-Jan Philogene-Bidace Groin Injury |
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| 14-Jan to 07-Feb Traore, B national team |
| February 2022 |
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| 08-Feb to 28-Feb Traore, B Lacking Match Fitness |
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| 11-Feb to 14-Mar Tuanzebe Injury |
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| 12-Feb to 14-Feb Targett Loan agreement |
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| 12-Feb to 20-Feb Konsa, E Red Card |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |