| Lineups found Starting lineup changes since last game |
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| October 2021 |
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| Coach Potter since 20-May-19 |
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 01-Aug to 27-Aug Veltman Covid-19 |
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| 07-Aug to 18-Sep Burn Knee Injury |
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| 07-Aug to 13-Aug Mac Allister, A Olympics |
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| 07-Aug to 10-Sep Scherpen Ankle Injury |
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| 21-Aug to 27-Aug Maupay Shoulder Injury |
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| 22-Aug to 10-Sep March Thigh Injury |
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| 24-Aug to 18-Sep Mwepu, E Knock |
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| 29-Aug to 21-Sep Groß, P Covid-19 |
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| 11-Sep to 23-Oct Webster, Adam (1995) Thigh Injury |
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| 19-Sep to 15-Oct Bissouma Knee Injury |
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| 20-Sep to 15-Oct Mwepu, E Groin Injury |
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| 22-Sep to 26-Sep Mac Allister, A Lower Back Injury |
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| 27-Sep to 14-Dec Alzate, S Ankle Injury |
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| 27-Sep to 25-Dec Welbeck Thigh Injury |
| November 2021 |
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| 27-Oct to 19-Nov Burn Knee Injury |
| December 2021 |
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| 14-Dec to 19-Jan Dunk Knee Injury |
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| 14-Dec to 18-Dec Webster, Adam (1995) Calf Injury |
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 14-Dec to 16-Dec Duffy, S Yellow Cards |
| January 2022 |
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| 25-Dec to 24-Jan Steele, J Back Injury |
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| 25-Dec to 24-Jan Bissouma national team |
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| 25-Dec to 27-Dec Veltman Thigh Injury |
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| 28-Dec to 30-Dec Trossard Thigh Injury |
| M.7 | 08-Jan | away | West Brom | | 1-2 | 3-5-2 | |
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| February 2022 |
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| 13-Jan to 10-Mar Mwepu, E Thigh Injury |
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| 17-Jan to 19-Jan Lallana Thigh Injury |
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| 17-Jan to 24-Jan Duffy, S Ankle Injury |
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| 24-Jan to 07-Feb Burn Toe Injury |
| M.8 | 05-Feb | away | Tottenham | | 3-1 | 3-5-1-1 | In:R Sánchez, Webster, Dunk, Cucurella, Lamptey, Lallana, Bissouma, Moder, Out:Scherpen, Veltman, Duffy, Burn, Offiah, Mwepu, Alzate, Welbeck, |
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| March 2022 |
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| 18-Feb to 20-Feb Dunk Red Card |
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| 25-Feb to 17-Mar Webster, Adam (1995) Groin Injury |
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| 15-Mar to 17-Mar Lallana Thigh Injury |
| April 2022 |
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| 01-Apr to 03-Apr Caicedo, Moisés Illness |
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| 01-Apr to 08-Apr Webster, Adam (1995) Groin Injury |
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| 08-Apr to 23-May Moder Knee Injury |
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| 15-Apr to 25-Apr Duffy, S Thigh Injury |
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| 15-Apr to 25-Apr Alzate, S Illness |
| May 2022 |
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| 19-Apr to 25-Apr Bissouma Yellow Cards |
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| 20-Apr to 29-Apr Lamptey, T Knee Injury |
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| 06-May to 16-May Mwepu, E Groin Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |