| Lineups found Starting lineup changes since last game |
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| November 2015 |
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| Coach Mourinho since 03-Jun-13 |
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 08-Nov to 20-Nov Zouma Knock |
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| 14-Nov to 20-Nov Hazard Illness |
| December 2015 |
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| 22-Nov to 05-Dec Ramires Muscle Injury |
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| 24-Nov to 05-Dec Terry Ankle Injury |
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 25-Nov to 04-Dec Rémy Personal Reasons |
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| 14-Dec to 26-Dec Hazard Hip Injury |
| January 2016 |
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| Coach Holland since 18-Dec-15 |
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| Coach Hiddink since 21-Dec-15 |
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| Coach Newton since 21-Dec-15 |
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| Coach Holland since 21-Dec-15 |
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| 27-Dec to 09-Jan Cahill, G Foot Injury |
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| 27-Dec to 12-Jan Rémy Calf Injury |
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| 03-Jan to 23-Jan Hazard Groin Injury |
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| 04-Jan to 12-Jan Matić, N Head Injury |
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| 10-Jan to 12-Jan Oscar, Emboaba Toe Injury |
| M.5 | 10-Jan | | Scunthorp | | 2-0 | 4-2-3-1 | |
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| 16-Jan to 23-Jan Diego Costa, (1988) Shin Injury |
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| 17-Jan to 30-Jan Pedro Illness |
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| 24-Jan to 30-Jan Diego Costa, (1988) Knee Injury |
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| 25-Jan to 12-Feb Rémy Calf Injury |
| M.7 | 31-Jan | away | MK Dons | | 1-5 | 4-2-3-1 | In:Courtois, Terry, B Rahman, Matić, Loft'ek, Hazard, Out:Begović, Zouma, Azpi'ta, Ramires, Willian, Pedro, |
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| February 2016 |
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| 01-Feb to 02-Feb Willian Foot Injury |
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| 13-Feb to 12-Mar Terry Muscle Injury |
| M.9 | 21-Feb | | Man.City | | 5-1 | 4-2-3-1 | In:Azpi'ta, Mikel, Pedro, Willian, Out:Terry, Matić, Oscar, Loft'ek, |
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| March 2016 |
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| 27-Feb to 08-Mar Pedro Hamstring Injury |
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| 01-Mar to 08-Mar Kenedy, NdN Groin Injury |
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| 02-Mar to 08-Mar Diego Costa, (1988) Tendon Injury |
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| 09-Mar to 22-Apr Hazard Hip Injury |
| M.11 | 12-Mar | away | Everton | | 2-0 | 4-2-3-1 | In:Kenedy, Matić, Out:B Rahman, Hazard, |
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| April 2016 |
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| 18-Mar to 02-Apr Diego Costa, (1988) Red Card Ban (2 matches) |
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| 19-Mar to 01-Apr Kenedy, NdN Head Injury |
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| 20-Mar to 01-May Terry Achilles Injury |
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| 23-Mar to 16-Apr Matić, N Knock |
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| 27-Mar to 16-Apr Cahill, G Tendon Injury |
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| 30-Mar to 16-Apr Willian Knock |
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| 02-Apr to 16-May Rémy Groin Injury |
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| 17-Apr to 01-May Cahill, G Illness |
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| 22-Apr to 02-May Courtois, T Red Card Ban (2 matches) |
| May 2016 |
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| 02-May to 10-May Pedro Knock |
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| 07-May to 14-May Ivanović, B Groin Injury |
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| 08-May to 15-May Diego Costa, (1988) Hamstring Injury |
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| 10-May to 15-May Terry Red Card Ban (2 matches) |
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| 10-May to 14-May Courtois, T Illness |
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| 11-May to 14-May Willian Hamstring Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |