| Lineups found Starting lineup changes since last game |
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| July 2011 |
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| Coach Villas Boas since 22-Jun-11 |
| August 2011 |
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 01-Aug to 20-Aug David Luiz Knee injury |
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 01-Aug to 27-Aug Sturridge 3 match ban from last season |
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| 18-Aug to 09-Sep Čech Medial Ligament |
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| 20-Aug to 09-Sep David Luiz Knee injury |
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| 27-Aug to 20-Sep Drogba Concussion |
| September 2011 |
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| 12-Sep to 14-Sep Ramires Champions League red card ban (1 match) |
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| 21-Sep to 01-Oct Sturridge Knee injury |
| M.4 | 21-Sep | | Fulham | | 0-0 | 4-1-2-3 | |
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| October 2011 |
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| 22-Sep to 25-Sep Alex 1 match domestic suspension (red card) |
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| 25-Sep to 24-Oct Torres 3 match domestic suspension (red card) |
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| 29-Sep to 27-Oct Hilario, H Hip injury |
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| 14-Oct to 16-Oct David Luiz Rested due to international travel |
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| 15-Oct to 25-Oct Ramires Knee injury |
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| 18-Oct to 20-Oct Terry Rested |
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| 18-Oct to 20-Oct Drogba Rested |
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| 25-Oct to 27-Oct Bosingwa 1 match domestic ban for red card |
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| 25-Oct to 27-Oct Drogba 3 match domestic suspension for red card (1st game) |
| M.5 | 26-Oct | away | Everton | | 1-2 | 4-1-2-3 | In:Turnbull, Ivan'c, Anelka, Out:Čech, P Ferreira, Sturridge, |
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| November 2011 |
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| 28-Oct to 30-Dec Hilario, H Illness |
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| 28-Oct to 30-Oct Turnbull 1 match domestic suspension for red card |
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| 28-Oct to 30-Oct Drogba 3 match domestic suspension for red card (2nd game) |
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| 31-Oct to 19-Nov Drogba Arm surgery |
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| 31-Oct to 02-Nov Mikel Rested |
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| 04-Nov to 06-Nov Drogba 3 match domestic suspension for red card (3rd game) |
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| 29-Nov to 25-Dec McEachran Ankle Injury |
| M.6 | 29-Nov | | Liverpool | | 0-2 | 4-1-2-3 | In:Bosingwa, Lampard, Torres, Out:Ivan'c, Anelka, Kalou, |
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| January 2012 |
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| 01-Dec to 31-Dec Anelka excluded from squad after transfer request |
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| 01-Dec to 31-Dec Alex excluded from squad after transfer request |
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| 04-Dec to 16-Dec David Luiz red card accumulation (1 match ban) |
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 12-Dec to 12-Dec Anelka to join Shanghai Shenhua in January 2012 |
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| 13-Dec to 21-Dec David Luiz Knee injury |
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| 13-Dec to 21-Dec Ramires Muscle injury |
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| 23-Dec to 20-Jan Ivanović, B Hamstring injury |
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| 23-Dec to 10-Feb Mikel Hamstring injury |
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| 06-Jan to 13-Feb Drogba African Cup of Nations |
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| 06-Jan to 13-Feb Kalou African Cup of Nations |
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| 22-Jan to 04-Feb Lampard Calf muscle tear |
| February 2012 |
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| 29-Jan to 17-Feb Ramires Medial Ligament damage |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |