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Chicago Fire Substitutions at Major League Soccer 2021
| Most In | | Most Out | | Offor | 11 times | 24 minutes avg | | Espinoza, Jhon | 10 | 20 | | Stojanović, L | 9 | 12 | | Gutiérrez, B | 8 | 17 | | Omsberg | 8 | 14 | | Aliseda | 6 | 32 | | Collier, E | 6 | 12 | | Herbers | 5 | 24 | | Bornstein | 5 | 12 | | Medrán | 5 | 19 | | Ivanov, Stanislav | 4 | 24 | | Berič | 4 | 28 | | Navarro, MA | 3 | 21 | | Kappelhof | 3 | 12 | | Giménez, G | 3 | 32 | | Terán, Carlos (2000) | 2 | 18 | | Navarro, Federico | 2 | 38 | | Pineda, Mauricio (1997) | 1 | 44 | | Casas, J | 1 | 44 | | Frankowski, P | 1 | 27 | | Sekulić, B | 1 | 32 |
| | | Medrán | 10 times | 74 minutes avg | | Berič | 9 | 70 | | Herbers | 8 | 66 | | Stojanović, L | 7 | 72 | | Offor | 6 | 74 | | Bornstein | 6 | 75 | | Kappelhof | 6 | 65 | | Sekulić, B | 6 | 68 | | Navarro, MA | 5 | 76 | | Pineda, Mauricio (1997) | 5 | 59 | | Espinoza, Jhon | 5 | 62 | | Terán, Carlos (2000) | 5 | 81 | | Omsberg | 4 | 62 | | Giménez, G | 4 | 66 | | Frankowski, P | 3 | 76 | | Gutiérrez, B | 3 | 55 | | Aliseda | 3 | 77 | | Ivanov, Stanislav | 2 | 68 | | Collier, E | 1 | 57 |
| | 34 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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