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Columbus Crew Substitutions at Major League Soccer 2021
| Most In | | Most Out | | Măţan | 13 times | 12 minutes avg | | Fraser, L | 10 | 25 | | Abdul-Salaam | 9 | 32 | | Francis, W | 8 | 32 | | Etienne, D | 6 | 33 | | Díaz, Luis (1998) | 6 | 24 | | Wright-Phillips, B | 5 | 9 | | Keita, Aboubacar | 5 | 24 | | Berry, M | 5 | 22 | | Hairston | 5 | 27 | | Williams, Josh (1988) | 4 | 25 | | Afful | 4 | 22 | | Molino | 4 | 16 | | Hurtado, E | 4 | 25 | | Parente, I | 3 | 15 | | Zardes | 2 | 39 | | Zelarayán | 2 | 38 | | Kitchen | 2 | 11 | | Santos, P | 2 | 28 | | Mensah, J | 1 | 17 | | Valenzuela, M | 1 | 1 | | Moreira, S | 1 | 17 |
| | | Hairston | 11 times | 69 minutes avg | | Francis, W | 9 | 70 | | Etienne, D | 9 | 71 | | Díaz, Luis (1998) | 8 | 66 | | Santos, P | 7 | 70 | | Wormgoor | 7 | 69 | | Fraser, L | 7 | 70 | | Măţan | 6 | 58 | | Valenzuela, M | 6 | 50 | | Afful | 5 | 67 | | Zelarayán | 5 | 81 | | Zardes | 4 | 70 | | Berry, M | 4 | 67 | | Artur, dL Jr | 3 | 70 | | Molino | 2 | 60 | | Kitchen | 2 | 46 | | Keita, Aboubacar | 2 | 53 | | Parente, I | 1 | 61 | | Wright-Phillips, B | 1 | 57 | | Abdul-Salaam | 1 | 65 | | Nagbe | 1 | 82 | | Moreira, S | 1 | 87 |
| | 34 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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