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Columbus Crew Substitutions at Major League Soccer 2022
| Most In | | Most Out | | Igbekeme | 15 times | 18 minutes avg | | Díaz, Luis (1998) | 9 | 22 | | Hurtado, E | 8 | 10 | | Morris, Aidan | 7 | 12 | | Yeboah, Y | 7 | 11 | | Sands, W | 7 | 29 | | Farsi | 7 | 11 | | Etienne, D | 6 | 25 | | Williams, Josh (1988) | 5 | 19 | | Măţan | 4 | 5 | | Zelarayán | 4 | 36 | | Molino | 4 | 11 | | Degenek | 3 | 39 | | Artur, dL Jr | 3 | 7 | | Anibaba | 2 | 2 | | Zardes | 2 | 26 | | Berry, M | 2 | 22 | | Hairston | 2 | 38 | | Zawadzki, S | 1 | 8 | | Santos, P | 1 | 12 |
| | | Díaz, Luis (1998) | 14 times | 77 minutes avg | | Artur, dL Jr | 11 | 73 | | Yeboah, Y | 10 | 69 | | Morris, Aidan | 8 | 82 | | Etienne, D | 7 | 76 | | Zelarayán | 5 | 85 | | Berry, M | 5 | 66 | | Santos, P | 5 | 51 | | Nagbe | 4 | 86 | | Mensah, J | 4 | 59 | | Degenek | 3 | 76 | | Moreira, S | 3 | 59 | | Igbekeme | 3 | 57 | | Zawadzki, S | 3 | 64 | | Hernández, Juan (1999) | 3 | 79 | | Sands, W | 3 | 85 | | Anibaba | 2 | 66 | | Molino | 2 | 74 | | Zardes | 1 | 59 | | Hurtado, E | 1 | 76 | | Hairston | 1 | 76 | | Williams, Josh (1988) | 1 | 46 |
| | 34 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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