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Defensa y Justicia Substitutions at Copa de la Liga Profesional 2021
| Most In | | Most Out | | Rius | 4 times | 28 minutes avg | | Hachen | 4 | 20 | | Merentiel | 4 | 22 | | Martínez, T | 3 | 26 | | Rotondi, C | 3 | 32 | | Benítez, Marcelo (1991) | 2 | 32 | | Larralde | 2 | 13 | | Escalante, Lautaro | 2 | 32 | | Brítez, E | 1 | 31 | | Meza, F | 1 | 34 | | Romero, Braian | 1 | 24 | | Loaiza, R | 1 | 44 | | Fernández, Enzo | 1 | 44 | | Isnaldo | 1 | 35 | | Pizzini | 1 | 35 | | Gallardo, N | 1 | 17 | | Paredes, FE | 1 | 17 | | Bou, W | 1 | 44 | | Frías, A | 1 | 44 | | Herrera, RE | 1 | 22 | | Echevarría, F | 1 | 5 | | Altamirano, G | 1 | 30 | | Fedele, L | 1 | 12 |
| | | Larralde | 5 times | 61 minutes avg | | Bou, W | 5 | 71 | | Isnaldo | 4 | 64 | | Brítez, E | 3 | 67 | | Pizzini | 2 | 70 | | Paredes, FE | 2 | 52 | | Breitenbruch | 2 | 77 | | Escalante, Lautaro | 2 | 58 | | Martínez, T | 2 | 57 | | Herrera, RE | 2 | 62 | | Ortiz, Tomás (2000) | 2 | 66 | | Loaiza, R | 1 | 68 | | Rodríguez, Juan (1994) | 1 | 56 | | González, Nicolás (1999) | 1 | 46 | | Rotondi, C | 1 | 55 | | Merentiel | 1 | 55 | | Tripichio, N | 1 | 73 | | Lencina, K | 1 | 46 | | Luayza | 1 | 60 |
| | 13 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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