| Lineups found Starting lineup changes since last game |
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| October 2021 |
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| Coach Benítez since 30-Jun-21 |
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 01-Aug to 12-Sep Godfrey, B Covid-19 |
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| 07-Aug to 13-Aug Branthwaite Ankle Surgery |
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| 07-Aug to 13-Aug Calvert-Lewin Toe Injury |
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 07-Aug to 13-Aug Richarlison Olympics |
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| 07-Aug to 23-Aug André Gomes Knock |
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| 07-Aug to 23-Aug Gbamin Knock |
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| 25-Aug to 27-Aug Iwobi Groin Injury |
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| 25-Aug to 12-Sep Mina, Y Knock |
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| 28-Aug to 21-Nov Calvert-Lewin Thigh Injury |
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| 02-Sep to 12-Sep Coleman, S Hamstring Strain |
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| 13-Sep to 22-Oct Richarlison Knee Injury |
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| 14-Sep to 24-Sep Pickford Shoulder Injury |
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| 14-Sep to 16-Oct Coleman, S Thigh Injury |
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| 14-Sep to 01-Oct Gbamin Thigh Injury |
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| 21-Sep to 01-Nov André Gomes Calf Injury |
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| 25-Sep to 16-Oct Iwobi Knock |
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| 26-Sep to 01-Oct Pickford Shoulder Injury |
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| 11-Oct to 13-Oct Mina, Y Knock |
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| 13-Oct to 16-Oct Doucoure, A Yellow Card Accumulation |
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| 18-Oct to 27-Nov Doucoure, A Ankle Injury |
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| 18-Oct to 01-Nov Mina, Y Thigh Injury |
| November 2021 |
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| December 2021 |
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| 11-Dec to 12-Jan Mina, Y Calf Injury |
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| 11-Dec to 27-Dec Calvert-Lewin Thigh Injury |
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| 15-Dec to 12-Jan Richarlison Calf Injury |
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| 15-Dec to 03-Jan Townsend, Andros Foot Injury |
| January 2022 |
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| 29-Dec to 31-Dec Gray, Demarai Illness |
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| 29-Dec to 31-Dec Rondón, S Thigh Injury |
| M.7 | 08-Jan | away | Hull City | | 2-3 | 3-4-3 | |
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| 09-Jan to 06-Feb Iwobi national team |
| February 2022 |
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| Coach Ferguson, Duncan since 18-Jan-22 |
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| Coach Clement since 31-Jan-22 |
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| Coach Lampard since 31-Jan-22 |
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| Coach Edwards, J since 31-Jan-22 |
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| Coach Ferguson, Duncan since 31-Jan-22 |
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| Coach Cole, A since 03-Feb-22 |
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| 14-Jan to 23-Jan Branthwaite Thigh Injury |
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| 22-Jan to 24-Feb Doucoure, A Groin Injury |
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| 23-Jan to 07-Feb Calvert-Lewin Knee Injury |
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| 24-Jan to 05-Feb Branthwaite Thigh Injury |
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| 05-Feb to 08-Mar Godfrey, B Thigh Injury |
| M.8 | 05-Feb | | Brentford | | 4-1 | 3-4-3 | In:Pickford, Holgate, Rich'on, Out:Begović, Kenny, Rondón, |
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| March 2022 |
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| 11-Feb to 18-Mar Mina, Y Muscle Injury |
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| 11-Feb to 20-Feb Gray, Demarai Muscle Injury |
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| 11-Feb to 13-Feb Mykolenko Illness |
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| 22-Feb to 03-Mar Calvert-Lewin Muscle Injury |
| M.9 | 03-Mar | | Bor.Wood | | 2-0 | 3-4-3 | In:Begović, Kenny, Bran'te, Patterson, Doucoure, Townsend, Rondón, Out:Pickford, Holgate, Godfrey, Coleman, A Gomes, Rich'on, Gray, |
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| 16-Mar to 18-Mar Kenny, J Red Card |
| M.10 | 20-Mar | away | C Palace | | 4-0 | 3-4-3 | In:Pickford, Godfrey, Holgate, Coleman, A Gomes, Rich'on, Out:Begović, Bran'te, Patterson, Allan, Mykolenko, Rondón, |
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| April 2022 |
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| 02-Apr to 07-Apr Allan, Marques Red Card |
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| 02-Apr to 10-Apr Mina, Y Muscle Injury |
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| 02-Apr to 23-May Townsend, Andros Knee Injury |
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| 05-Apr to 07-Apr Keane, M Red Card |
| May 2022 |
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| 21-Apr to 23-May Mina, Y Knock |
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| 21-Apr to 18-May Godfrey, B Thigh Injury |
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| 23-Apr to 30-Apr Calvert-Lewin Thigh Injury |
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| 23-Apr to 02-May André Gomes Groin Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |