| Lineups found Starting lineup changes since last game |
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| July 2021 |
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| Coach Benítez since 30-Jun-21 |
| August 2021 |
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| Coach Moreno since 14-Jul-21 |
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 01-Aug to 12-Sep Godfrey, B Covid-19 |
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| 07-Aug to 13-Aug Branthwaite Ankle Surgery |
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| 07-Aug to 23-Aug André Gomes Knock |
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| 07-Aug to 23-Aug Gbamin Knock |
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| 07-Aug to 20-Aug Kean, M Knock |
| M.2 | 24-Aug | away | Huddersfd | | 1-2 | 3-4-3 | |
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| 25-Aug to 27-Aug Iwobi Groin Injury |
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 25-Aug to 29-Aug Kean, M Red Card Ban |
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| 25-Aug to 12-Sep Mina, Y Knock |
| September 2021 |
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| 02-Sep to 12-Sep Coleman, S Hamstring Strain |
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| 14-Sep to 16-Oct Coleman, S Thigh Injury |
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| 14-Sep to 01-Oct Gbamin Thigh Injury |
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| 21-Sep to 24-Sep Digne Calf Injury |
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| 21-Sep to 01-Nov André Gomes Calf Injury |
| M.3 | 21-Sep | away | QPR | | 2-2 | 4-2-3-1 | In:Godfrey, Digne, A Gomes, Gordon, Rondón, Out:Keane, Bran'te, Gbamin, Nkounkou, Kean, M, |
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| October 2021 |
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| 25-Sep to 16-Oct Iwobi Knock |
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| 03-Oct to 16-Oct Digne Thigh Injury |
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| 11-Oct to 13-Oct Mina, Y Knock |
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| 13-Oct to 16-Oct Doucoure, A Yellow Card Accumulation |
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| 18-Oct to 27-Nov Doucoure, A Ankle Injury |
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| 18-Oct to 01-Nov Mina, Y Thigh Injury |
| December 2021 |
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| 11-Dec to 12-Jan Mina, Y Calf Injury |
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| 11-Dec to 18-Mar Davies, Tom (1998) Thigh Injury |
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| 11-Dec to 13-Dec Digne Suspended |
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| 15-Dec to 03-Jan Townsend, Andros Foot Injury |
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| 15-Dec to 27-Dec Digne Illness |
| January 2022 |
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| 29-Dec to 31-Dec Gray, Demarai Illness |
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| 29-Dec to 31-Dec Rondón, S Thigh Injury |
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| 09-Jan to 06-Feb Iwobi national team |
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| Coach Ferguson, Duncan since 18-Jan-22 |
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| 14-Jan to 23-Jan Branthwaite Thigh Injury |
| February 2022 |
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| Coach Clement since 31-Jan-22 |
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| Coach Lampard since 31-Jan-22 |
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| Coach Edwards, J since 31-Jan-22 |
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| Coach Ferguson, Duncan since 31-Jan-22 |
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| Coach Cole, A since 03-Feb-22 |
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| 22-Jan to 24-Feb Doucoure, A Groin Injury |
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| 24-Jan to 05-Feb Branthwaite Thigh Injury |
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| 05-Feb to 08-Mar Godfrey, B Thigh Injury |
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| 11-Feb to 18-Mar Mina, Y Muscle Injury |
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| 11-Feb to 20-Feb Gray, Demarai Muscle Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |