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Independiente Medellin Substitutions at Apertura 2021
| Most In | | Most Out | | Pineda, Jean | 6 times | 27 minutes avg | | Sánchez, James | 5 | 32 | | Castro, LF | 5 | 30 | | Reina, J | 5 | 36 | | Mosquera, Edwin | 4 | 24 | | Díaz, JC (2001) | 3 | 35 | | Gallego, JP | 3 | 26 | | Loaiza, DA | 2 | 27 | | Díaz, Yesid | 2 | 30 | | Gómez, Y | 2 | 18 | | Harrys | 2 | 29 | | Mier | 2 | 16 | | Mosquera, JD | 2 | 47 | | Vuletich | 1 | 33 | | Giraldo, JA | 1 | 19 | | Vásquez, LH | 1 | 22 | | Cuesta, JM | 1 | 0 | | Rolín, A | 1 | 0 | | Estupiñán, JG | 1 | 6 | | Monsalve, MA | 1 | 6 | | Londoño, K | 1 | 19 |
| | | Mier | 7 times | 69 minutes avg | | Londoño, K | 7 | 65 | | Díaz, Yesid | 4 | 56 | | Ospina, JD | 4 | 56 | | Harrys | 4 | 60 | | Pineda, Jean | 4 | 62 | | Sánchez, James | 4 | 74 | | Reina, J | 4 | 67 | | Díaz, JC (2001) | 2 | 57 | | Gallego, JP | 2 | 56 | | Castro, LF | 2 | 82 | | Monsalve, MA | 1 | 68 | | Moreno, VA | 1 | 71 | | Vuletich | 1 | 61 | | Mosquera, Andrés (1991) | 1 | 68 | | Mosquera, Edwin | 1 | 55 | | Gutiérrez, GA | 1 | 18 | | Loaiza, DA | 1 | 71 |
| | 18 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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