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Independiente Medellin Substitutions at Finalizacion 2021
| Most In | | Most Out | | Hernández, Sebastián (1986) | 7 times | 18 minutes avg | | Cambindo, D | 6 | 18 | | Gallego, JP | 6 | 22 | | Londoño, K | 6 | 35 | | Pineda, Jean | 4 | 22 | | Reina, J | 4 | 32 | | Díaz, JC (2001) | 4 | 18 | | Castro, LF | 3 | 27 | | Díaz, Yesid | 3 | 37 | | Harrys | 2 | 18 | | Camargo, Miguel | 2 | 27 | | Bueno, DA | 2 | 44 | | Mosquera, JD | 2 | 14 | | Loaiza, DA | 1 | 27 | | Hernández, V | 1 | 44 | | Herazo | 1 | 44 | | Jiménez, Leiton | 1 | 2 | | Vuletich | 1 | 17 | | López, Edwar | 1 | 9 |
| | | Vuletich | 7 times | 75 minutes avg | | López, Edwar | 6 | 62 | | Hernández, V | 6 | 70 | | Arregui | 5 | 78 | | Reina, J | 5 | 68 | | Castro, LF | 4 | 70 | | Loaiza, DA | 3 | 47 | | Pineda, Jean | 3 | 85 | | Hernández, Sebastián (1986) | 2 | 68 | | Cambindo, D | 2 | 74 | | Díaz, JC (2001) | 2 | 46 | | Moreno, VA | 2 | 35 | | Bueno, DA | 2 | 76 | | Londoño, K | 2 | 58 | | Gómez, Y | 2 | 60 | | Gallego, JP | 1 | 46 | | Camargo, Miguel | 1 | 46 | | Jiménez, Leiton | 1 | 27 | | Díaz, Yesid | 1 | 68 |
| | 20 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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