| Lineups found Starting lineup changes since last game |
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| September 2010 |
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| Coach Benítez since 08-Jun-10 |
| M.1 | 14-Sep | away | Twente | | 2-2 | 4-2-3-1 | |
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 15-Sep to 18-Sep Pandev right collateral ligament knee strain |
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 19-Sep to 19-Sep Zanetti taken to hospital following today game after chest pains |
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| 20-Sep to 20-Sep Nagatomo 2nd Yellow Card assigned by Lega Serie A Federal Committee |
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| 20-Sep to 05-Oct Zanetti post-traumatic pneumothorax |
| M.2 | 29-Sep | | Werder | | 4-0 | 4-2-3-1 | In:Córdoba, Chivu, Stan'ic, P Coutinho, Biabiany, Out:Samuel, Zanetti, Mariga, Pandev, Milito, |
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| October 2010 |
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| 04-Oct to 19-Oct Córdoba, I left biceps femoris muscle strain |
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| 09-Oct to 22-Oct Cambiasso left biceps femoris muscle strain |
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| 09-Oct to 27-Oct Milito, D left biceps femoris muscle strain |
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| 13-Oct to 15-Nov Mariga left biceps femoris muscle strain |
| M.3 | 20-Oct | | Tottenham | | 4-3 | 4-2-3-1 | In:Samuel, Zanetti, Out:Córdoba, Cambiasso, |
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| November 2010 |
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| 21-Oct to 08-Nov Kharja right thigh flexor muscle injury |
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| 21-Oct to 08-Nov Stanković right calf flexor muscle strain |
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| 27-Oct to 26-Nov Thiago Motta right knee pain |
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| 30-Oct to 10-Nov Júlio César, Soares right thigh strain |
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| 30-Oct to 11-Nov Cambiasso left thigh strain |
| M.4 | 02-Nov | away | Tottenham | | 3-1 | 4-2-3-1 | In:Cast'zi, Muntari, Pandev, Out:Juli', , Stan'ic, P Coutinho, |
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| 03-Nov to 25-Nov Muntari right calf |
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| 07-Nov to 25-Apr Samuel right anterior cruciate and outer collateral ligaments torn |
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| 07-Nov to 26-Nov Maicon left thigh strain |
| M.5 | 24-Nov | | Twente | | 1-0 | 4-2-3-1 | In:Córdoba, Materazzi, Stan'ic, Cambiasso, Out:Maicon, Samuel, Chivu, Muntari, |
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| December 2010 |
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 25-Nov to 06-Dec Eto'o Federal Judge Ban for violent behaviour (2 of 3 matches) |
| M.6 | 07-Dec | away | Werder | | 3-0 | 4-4-2 | In:Orlandoni, Biraghi, Santon, T Motta, Nwankwo, Muntari, Out:Cast'zi, Lúcio, Materazzi, Stan'ic, Biabiany, Sneijder, |
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| February 2011 |
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| Coach Leonardo since 24-Dec-10 |
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| 19-Dec to 31-Jan Sneijder left leg biceps femoris muscle strain |
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| 27-Dec to 27-Dec Ranocchia joining Inter Milan on January 1st |
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| 01-Jan to 31-Jan Nagatomo representing Japan in 2011 AFC Asian Cup in Qatar |
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| 05-Jan to 07-Jan Eto'o Federal Judge Ban for violent behaviour (3rd of 3 matches) |
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| 05-Jan to 28-Jan Júlio César, Soares left leg biceps femoris muscle strain |
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| 27-Jan to 04-Feb Córdoba, I right shoulder injury |
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| 27-Jan to 14-Feb Stanković right thigh semimembranosus muscle strain |
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| 28-Jan to 30-Jan Chivu 4th yellow card ban (1 match) |
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| 28-Jan to 30-Jan Córdoba, I 4th yellow card ban (1 match) |
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| 28-Jan to 30-Jan Stanković 4th yellow card ban (1 match) |
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| 28-Jan to 14-Feb Mariga right leg biceps femoris muscle strain |
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| 31-Jan to 31-Jan Nagatomo joins Inter Milan (loan) |
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| 31-Jan to 17-Feb Lúcio right thigh adductor muscle strain |
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| 04-Feb to 20-Feb Chivu Federal Judge ban for violent conduct (4 matches) |
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| 07-Feb to 20-Mar Milito, D left thigh biceps femoris muscle strain |
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| 14-Feb to 16-Feb Thiago Motta 4th yellow card ban (1 match) |
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| 17-Feb to 23-Feb Sneijder right adductor muscle fatigue |
| M.7 | 23-Feb | | Bayern | | 0-1 | 4-3-2-1 | In:Juli', , Maicon, Ranocchia, Lúcio, Chivu, Sneijder, Stan'ic, Out:Orlandoni, Córdoba, Biraghi, Santon, Nwankwo, Muntari, Pandev, |
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| March 2011 |
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| 25-Feb to 28-Feb Maicon 4th yellow card ban (1 match) |
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| 25-Feb to 14-Mar Cambiasso left thigh adductor muscle strain |
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| 14-Mar to 16-Mar Zanetti flu |
| M.8 | 15-Mar | away | Bayern | | 2-3 | 4-2-3-1 | In:Pandev, Out:Zanetti, |
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| April 2011 |
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| 18-Mar to 20-Mar Córdoba, I red card ban (1 match) |
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| 01-Apr to 03-Apr Lúcio 4th yellow card ban (1 match) |
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| 04-Apr to 06-Apr Lúcio Champions League yellow card ban (1 match) |
| M.9 | 05-Apr | | Schalke | | 2-5 | 4-3-1-2 | In:Zanetti, Milito, Out:Lúcio, Pandev, |
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| 08-Apr to 10-Apr Chivu red card ban (1 match) |
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| 11-Apr to 13-Apr Chivu Champions League red card ban (1 match) |
| M.10 | 13-Apr | away | Schalke | | 2-1 | 4-3-1-2 | In:Lúcio, Nagatomo, Out:Chivu, Cambiasso, |
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| 21-Apr to 28-Apr Thiago Motta left hip pain |
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| 26-Apr to 17-May Stanković left adductor muscle strain |
| May 2011 |
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| 29-Apr to 02-May Júlio César, Soares red card ban (1 match) |
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| 30-Apr to 10-May Sneijder calf |
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| 06-May to 09-May Mariga 4th yellow card ban (1 match) |
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| 09-May to 11-May Ranocchia Coppa Italia yellow card ban (1 match) |
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| 12-May to 12-May Zanetti 1000th match (Talleres33 Banfield66 Inter749 Argentina152) |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |