| Lineups found Starting lineup changes since last game |
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| September 2010 |
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| Coach Delneri since 19-May-10 |
| M.1 | 16-Sep | | L.Poznan | | 3-3 | 4-4-2 | |
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 17-Sep to 29-Sep De Ceglie right adductor muscle strain |
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| 27-Sep to 15-Mar Rinaudo back surgery (hernia) |
| M.2 | 30-Sep | away | Man.City | | 1-1 | 4-4-2 | In:Bonucci, Marchisio, Mart'z, Out:Legr'ie, F Melo, Lanzafame, |
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| October 2010 |
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| 15-Oct to 08-Nov Lanzafame left ankle sprain |
| M.3 | 21-Oct | away | Salzburg | | 1-1 | 4-4-2 | In:Pepe, S, Amauri, Out:Krasić, Iaquinta, |
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| November 2010 |
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| 22-Oct to 20-Nov Grygera right knee strain |
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 28-Oct to 31-Oct Krasić, M Federal Judge ban for diving (1st of 2 matches) |
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| 31-Oct to 21-Apr De Ceglie left patellar fracture |
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| 31-Oct to 13-Jan Martínez, Jorge (1983apr) left foot metatarsical fracture |
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| 01-Nov to 21-Nov Manninger right ankle strain |
| M.4 | 04-Nov | | Salzburg | | 0-0 | 4-4-2 | In:Storari, Motta, Legr'ie, Krasić, Gian'to, Out:Manninger, Grygera, Chiellini, D Ceglie, Mart'z, |
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| December 2010 |
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| 05-Nov to 07-Nov Krasić, M Federal Judge ban for diving (2nd of 2 matches) |
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| 06-Nov to 10-Dec Legrottaglie right biceps femoris muscle strain |
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| 06-Nov to 19-Nov Krasić, M left thigh adductor muscle strain |
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| 12-Nov to 14-Nov Motta 4th yellow card ban (1 match) |
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| 16-Nov to 21-Nov Pepe, S 4th yellow card ban (1 match) |
| M.5 | 01-Dec | away | L.Poznan | | 1-1 | 4-4-2 | In:Manninger, Camilleri, Chiellini, Traoré, Iaquinta, Out:Storari, Motta, Legr'ie, Gian'to, Amauri, |
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| 03-Dec to 06-Dec Marchisio 4th yellow card ban (1 match) |
| M.6 | 16-Dec | | Man.City | | 1-1 | 4-4-2 | In:Grygera, Legr'ie, F Melo, Giannetti, Out:Camilleri, Bonucci, Marchisio, Iaquinta, |
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| February 2011 |
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| 17-Dec to 19-Dec Felipe Melo 4th yellow card ban (1 match) |
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| 02-Jan to 25-Jan Iaquinta left thigh strain |
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| 05-Jan to 07-Jan Giandonato red card ban (1 match) |
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| 05-Jan to 07-Jan Bonucci 4th yellow card ban (1 match) |
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| 07-Jan to 09-Jan Felipe Melo Federal Judge ban for violent behaviour (1st of 3 match ban) |
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| 14-Jan to 23-Jan Felipe Melo Federal Judge ban for violent behaviour (2 of 3 match ban) |
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| 18-Jan to 15-Mar Giandonato meniscus |
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| 24-Jan to 16-Feb Traoré, Armand right thigh adductor muscle strain |
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| 28-Jan to 07-Feb Iaquinta right knee patellar ligament pain |
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| 29-Jan to 14-Feb Pepe, S right adductor muscle strain |
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| 31-Jan to 03-Feb Bonucci red card ban (1 match) |
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| 02-Feb to 09-Feb Legrottaglie head injury caused by Lazio forward Kozák |
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| 18-Feb to 20-Feb Sissoko 4th yellow card ban (1 match) |
| March 2011 |
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| 25-Feb to 05-May Sissoko left knee cartilage |
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| 03-Mar to 06-Mar Pepe, S 8th yellow card ban (1 match) |
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| 07-Mar to 17-Mar Felipe Melo talus bone trauma |
| April 2011 |
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| 18-Mar to 20-Mar Motta red card ban (1 match) |
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| 30-Mar to 28-Apr Chiellini right thigh rectus femoris muscle strain |
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| 22-Apr to 17-May Martínez, Jorge (1983apr) left calf |
| May 2011 |
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| 13-May to 15-May Lanzafame red card ban (1 match) |
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| 13-May to 15-May Krasić, M 4th yellow card ban (1 match) |
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| 13-May to 15-May Marchisio 8th yellow card ban (1 match) |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |