| Lineups found Starting lineup changes since last game |
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| September 2015 |
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| Coach van Gaal since 19-May-14 |
| M.1 | 15-Sep | away | PSV | | 2-1 | 4-2-3-1 | |
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 20-Sep to 16-Oct Rojo Hamstring Injury |
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| 21-Sep to 03-Oct McNair Knock |
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| 24-Sep to 16-Oct Herrera, Ander Knock |
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| 26-Sep to 03-Oct Carrick Knock |
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| 27-Sep to 29-Sep Valencia, Luis (1985) Knock |
| M.2 | 30-Sep | | Wolfsburg | | 2-1 | 4-2-3-1 | In:Valencia, Schn'in, Rooney, Out:Shaw, L, Herrera, Young, |
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| October 2015 |
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| 05-Oct to 16-Oct Carrick Groin Injury |
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| 05-Oct to 16-Oct Rooney Ankle Injury |
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| 05-Oct to 16-Oct Schweinsteiger Groin Strain |
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| 05-Oct to 27-Oct Wilson, James (1995) Illness |
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| 05-Oct to 27-Oct Young, A Calf Injury |
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| 12-Oct to 20-Nov McNair Abdominal Strain |
| M.3 | 21-Oct | away | CSKA | | 1-1 | 4-2-3-1 | In:Jones, Rojo, Lingard, Herrera, Out:Blind, Darmian, Mata, Depay, |
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| November 2015 |
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| 26-Oct to 10-Mar Valencia, Luis (1985) Foot Injury |
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| 28-Oct to 02-Nov Depay Knock |
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| 28-Oct to 24-Nov Wilson, James (1995) Knee Injury |
| M.4 | 03-Nov | | CSKA | | 1-0 | 4-2-3-1 | In:Young, Blind, Carrick, Mata, Out:Valencia, Jones, Schn'in, Herrera, |
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| 04-Nov to 24-Nov Fellaini Calf Injury |
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| 13-Nov to 28-Nov Carrick Ankle Injury |
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| 13-Nov to 20-Nov Smalling Knock |
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| 17-Nov to 24-Nov Martial, A Foot Injury |
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| 18-Nov to 24-Nov Rooney Illness |
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| 21-Nov to 11-Dec Jones, Phil Ankle Injury |
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| 21-Nov to 18-Dec Herrera, Ander Hamstring Injury |
| M.5 | 25-Nov | | PSV | | 0-0 | 4-2-3-1 | In:Darmian, Schn'in, Depay, Out:Young, Carrick, Mata, |
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| December 2015 |
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| 26-Nov to 24-Feb Rojo Shoulder Injury |
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| 26-Nov to 04-Dec Lingard Hamstring Injury |
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| 28-Nov to 18-Dec Rooney Ankle Injury |
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| 05-Dec to 11-Dec Schneiderlin Hip Injury |
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| 08-Dec to 26-Dec Darmian Hamstring Injury |
| M.6 | 08-Dec | away | Wolfsburg | | 3-2 | 4-1-4-1 | In:Varela, Mata, Fellaini, Out:Rojo, Schn'in, Rooney, |
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| 09-Dec to 18-Dec Smalling Groin Injury |
| February 2016 |
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 11-Dec to 27-Dec Schweinsteiger Fa Conduct Ban (3 matches) |
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| 12-Dec to 11-Jan Lingard Hamstring Injury |
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| 13-Dec to 18-Dec Young, A Knock |
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| 02-Jan to 03-Apr Jones, Phil Foot Injury |
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| 02-Jan to 11-Jan Young, A Knock |
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| 03-Jan to 28-Jan Carrick Knock |
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| 04-Jan to 19-Feb Powell, N Calf Injury |
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| 09-Jan to 09-Mar Schweinsteiger Knee Injury |
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| 17-Jan to 21-Jan Young, A knee injury |
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| 22-Jan to 02-Apr Young, A groin injury |
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| 23-Jan to 01-Feb Darmian Head Injury |
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| 30-Jan to 21-Feb Varela, Guillermo Knock |
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| 07-Feb to 05-Mar Fellaini Muscle Injury |
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| 13-Feb to 01-Mar Darmian Dislocated Shoulder |
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| 14-Feb to 21-Feb Borthwick-Jackson Illness |
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| 14-Feb to 27-Feb De Gea, D Knee Injury |
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| 14-Feb to 12-Apr Rooney Knee Injury |
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| 22-Feb to 03-Apr Borthwick-Jackson Knock |
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| 22-Feb to 01-Mar Martial, A Hamstring Injury |
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| 23-Feb to 05-Mar Smalling Shoulder Injury |
| March 2016 |
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| 28-Feb to 01-Mar Rojo Ankle Injury |
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| 09-Mar to 11-Mar Lingard Yellow cards ban |
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| 14-Mar to 02-Apr Herrera, Ander Groin Injury |
| April 2016 |
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| 21-Mar to 16-May Schweinsteiger Knee Injury |
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| 13-Apr to 19-Apr Herrera, Ander Leg Injury |
| May 2016 |
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| 02-May to 20-May Fellaini Violent Conduct Ban (3 matches) |
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| 02-May to 09-May Martial, A Hamstring Injury |
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| Coach Mourinho since 26-May-16 |
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| Coach Formosinho since 26-May-16 |
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| 07-May to 15-May Darmian Ankle Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |