| Lineups found Starting lineup changes since last game |
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| November 2018 |
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| Coach Mourinho since 26-May-16 |
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 25-Nov to 30-Dec Sánchez , Alexis Thigh Injury |
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| 25-Nov to 15-Dec Lindelöf Thigh Injury |
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| 25-Nov to 04-Dec Darmian Knock |
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| 28-Nov to 04-Dec Smalling Foot Injury |
| December 2018 |
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| 01-Dec to 04-Dec Rashford Knock |
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| 01-Dec to 21-Dec Shaw, L Muscle Injury |
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| 02-Dec to 07-Dec Jones, Phil Knock |
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 04-Dec to 05-Dec Young, A Yellow Card Accumulation (1 match) |
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| 05-Dec to 15-Dec Martial, A Thigh Injury |
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| 06-Dec to 07-Dec Smalling Knock |
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| 06-Dec to 08-Dec Bailly, E Knock |
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| 06-Dec to 15-Dec Darmian Knock |
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| 08-Dec to 28-Jan Smalling Foot Injury |
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| 09-Dec to 05-Jan McTominay Knock |
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| 09-Dec to 15-Dec Dalot Knock |
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| 12-Dec to 26-Feb Rojo Knock |
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| 17-Dec to 29-Dec Lukaku Compassionate Leave |
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| Coach Phelan since 18-Dec-18 |
| January 2019 |
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| Coach Solskjær since 19-Dec-18 |
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| Coach Dempsey since 19-Dec-18 |
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| 22-Dec to 29-Dec Martial, A Illness |
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| 31-Dec to 18-Jan Bailly, E Red Card Ban |
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| 05-Jan to 18-Jan Sánchez , Alexis Thigh Injury |
| M.5 | 05-Jan | | Reading | | 2-0 | 4-3-3 | |
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| 06-Jan to 24-Feb Fellaini Calf Injury |
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| 14-Jan to 24-Jan Shaw, L Illness |
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| 19-Jan to 24-Jan Rashford Knee Injury |
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| 20-Jan to 12-Apr Darmian Knock |
| M.7 | 25-Jan | away | Arsenal | | 1-3 | 4-3-1-2 | In:Bailly, Lindelöf, Shaw, L, Herrera, Matić, Pogba, Lingard, Out:Dalot, Darmian, Jones, McTominay, A Pereira, Fred, Mata, |
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| 26-Jan to 02-Feb Martial, A Knock |
| February 2019 |
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| 30-Jan to 02-Feb Pogba, P Muscle Injury |
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| 10-Feb to 10-Mar Jones, Phil Illness |
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| 12-Feb to 23-Feb Lingard Thigh Injury |
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| 12-Feb to 10-Mar Martial, A Groin Injury |
| M.9 | 18-Feb | away | Chelsea | | 0-2 | 4-3-1-2 | In:Smalling, Mata, Rashford, Out:Bailly, Lingard, Sanc' , |
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| March 2019 |
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| 19-Feb to 10-Mar Matić, N Knock |
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| 24-Feb to 10-Mar Herrera, Ander Hamstring Strain |
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| 24-Feb to 15-Mar Mata Hamstring Strain |
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| 24-Feb to 15-Mar Lingard Hamstring Strain |
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| 25-Feb to 26-Feb Rashford Ankle Injury |
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| 02-Mar to 13-Apr Sánchez , Alexis Knee Injury |
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| 05-Mar to 07-Mar Pogba, P Uefa card suspension |
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| 06-Mar to 28-Apr Bailly, E Concussion |
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| 11-Mar to 29-Mar Lukaku Foot Injury |
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| 16-Mar to 29-Mar Matić, N Knock |
| M.10 | 16-Mar | away | Wolves | | 2-1 | 4-3-1-2 | In:Dalot, Lingard, Martial, Out:Young, Mata, Lukaku, |
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| 17-Mar to 29-Mar Martial, A Knee Injury |
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| 17-Mar to 29-Mar Shaw, L Knock |
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| 17-Mar to 29-Mar Rashford Ankle Injury |
| April 2019 |
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| 30-Mar to 28-Apr Herrera, Ander Thigh Injury |
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| 03-Apr to 13-Apr Matić, N Knock |
| May 2019 |
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| 11-Apr to 23-Apr Shaw, L Domestic Yellow Card Accumulation (2 matches) |
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| 12-Apr to 13-Apr Young, A Red Card Ban (1 match) |
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| 21-Apr to 04-May Jones, Phil Knock |
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| 22-Apr to 27-Apr McTominay Knock |
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| 24-Apr to 12-May Lingard Knee Injury |
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| 25-Apr to 12-May Martial, A Knock |
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| 29-Apr to 12-May Lukaku Thigh Injury |
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| 29-Apr to 12-May Romero, Sergio Knee Injury |
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| 05-May to 12-May Sánchez , Alexis Ankle Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |