| Lineups found Starting lineup changes since last game |
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| August 2015 |
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| Coach van Gaal since 19-May-14 |
| September 2015 |
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 31-Aug to 12-Sep Carrick Calf Injury |
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 01-Sep to 01-Sep Martial, A joining Manchester United, £36m |
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| 09-Sep to 20-Sep Rooney Hamstring Injury |
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| 20-Sep to 16-Oct Rojo Hamstring Injury |
| M.3 | 23-Sep | | Ipswich | | 3-0 | 4-2-3-1 | |
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| October 2015 |
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| 24-Sep to 16-Oct Herrera, Ander Knock |
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| 26-Sep to 03-Oct Carrick Knock |
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| 27-Sep to 29-Sep Valencia, Luis (1985) Knock |
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| 05-Oct to 16-Oct Carrick Groin Injury |
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| 05-Oct to 16-Oct Rooney Ankle Injury |
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| 05-Oct to 16-Oct Schweinsteiger Groin Strain |
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| 05-Oct to 27-Oct Wilson, James (1995) Illness |
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| 05-Oct to 27-Oct Young, A Calf Injury |
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| 28-Oct to 02-Nov Depay Knock |
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| 28-Oct to 24-Nov Wilson, James (1995) Knee Injury |
| M.4 | 28-Oct | | Middlsbro | | 0-0 | 4-2-3-1 | In:Romero, Darmian, Rojo, Carrick, Lingard, Depay, Wilson, Out:D Gea, Valencia, Young, Schw'er, Herrera, Mata, Rooney, |
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| December 2015 |
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| 04-Nov to 24-Nov Fellaini Calf Injury |
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| 13-Nov to 28-Nov Carrick Ankle Injury |
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| 13-Nov to 20-Nov Smalling Knock |
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| 17-Nov to 24-Nov Martial, A Foot Injury |
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| 18-Nov to 24-Nov Rooney Illness |
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| 21-Nov to 11-Dec Jones, Phil Ankle Injury |
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| 21-Nov to 18-Dec Herrera, Ander Hamstring Injury |
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| 26-Nov to 24-Feb Rojo Shoulder Injury |
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| 26-Nov to 04-Dec Lingard Hamstring Injury |
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| 28-Nov to 18-Dec Rooney Ankle Injury |
| January 2016 |
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| 05-Dec to 11-Dec Schneiderlin Hip Injury |
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| 08-Dec to 26-Dec Darmian Hamstring Injury |
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| 09-Dec to 18-Dec Smalling Groin Injury |
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 11-Dec to 27-Dec Schweinsteiger Fa Conduct Ban (3 matches) |
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| 12-Dec to 11-Jan Lingard Hamstring Injury |
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| 13-Dec to 18-Dec Young, A Knock |
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| 02-Jan to 11-Jan Young, A Knock |
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| 03-Jan to 28-Jan Carrick Knock |
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| 17-Jan to 21-Jan Young, A knee injury |
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| 23-Jan to 01-Feb Darmian Head Injury |
| February 2016 |
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| 14-Feb to 27-Feb De Gea, D Knee Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |