| Lineups found Starting lineup changes since last game |
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| July 2021 |
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| Coach Solskjær since 19-Dec-18 |
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 27-Jul to 25-Sep Alex Telles Ankle Injury |
| August 2021 |
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| 07-Aug to 10-Sep Henderson, D Knock |
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| 07-Aug to 21-Aug Lingard Knock |
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| 07-Aug to 13-Aug Sancho, J Knock |
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| 11-Aug to 29-Aug Bailly, E Fatigue |
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| 23-Aug to 19-Sep McTominay Groin Injury |
| September 2021 |
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| 29-Aug to 10-Sep Sancho, J Knock |
| M.3 | 22-Sep | | West Ham | | 0-1 | 4-3-3 | |
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| October 2021 |
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| 02-Oct to 30-Oct Martial, A Knock |
| December 2021 |
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| Coach Carrick since 21-Nov-21 |
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| Coach Rangnick since 03-Dec-21 |
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| Coach Armas, C since 07-Dec-21 |
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| Coach Sharp since 15-Dec-21 |
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| 18-Dec to 18-Dec Wan-Bissaka Knock |
| January 2022 |
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| 26-Dec to 16-Jan Martial, A Muscle Injury |
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| 26-Dec to 04-Jan Lindelöf Illness |
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 29-Dec to 31-Dec Bruno Fernandes, (1994) Yellow Cards |
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| 02-Jan to 04-Jan Bailly, E Injury |
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| 09-Jan to 09-Feb Bailly, E national team |
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| 14-Jan to 16-Jan McTominay Yellow Cards |
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| 18-Jan to 02-Feb Wan-Bissaka Illness |
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| 20-Jan to 09-Feb Lindelöf Illness |
| February 2022 |
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| 21-Jan to 01-Feb Sancho, J Personal Reasons |
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| 23-Jan to 07-Feb Lingard Personal Leave |
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| 23-Jan to 16-Mar Greenwood, M Club Suspension |
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| 07-Feb to 13-Feb Alex Telles Illness |
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| 11-Feb to 16-Feb Bailly, E Ankle Injury |
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| 11-Feb to 18-Feb Matić, N Shin Injury |
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| 17-Feb to 21-Feb Heaton, Tom Groin Injury |
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| 22-Feb to 03-Mar McTominay Illness |
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| 23-Feb to 05-Mar Martial, A Thigh Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |