| Lineups found Starting lineup changes since last game |
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| September 2011 |
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| Coach Mazzarri since 06-Oct-09 |
| M.1 | 14-Sep | away | Man.City | | 1-1 | 3-4-3 | |
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 19-Sep to 22-Sep Campagnaro Rested |
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| 19-Sep to 22-Sep Dossena Rested |
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| 19-Sep to 22-Sep Lavezzi Rested |
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 21-Sep to 15-Dec Donadel Thigh injury |
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| 22-Sep to 30-Sep Maggio right thigh muscle pain |
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| 22-Sep to 14-Oct Džemaili Ankle injury |
| M.2 | 27-Sep | | Villarreal | | 2-0 | 3-4-2-1 | In:Dossena, Out:Maggio, |
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| 28-Sep to 06-Oct Cavani right ankle sprain |
| October 2011 |
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| 05-Oct to 31-Oct Pandev left leg biceps femoris muscle strain |
| M.3 | 18-Oct | | Bayern | | 1-1 | 3-4-2-1 | In:Maggio, Out:Dossena, |
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| November 2011 |
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| 23-Oct to 16-Nov Gargano left adductor muscle strain |
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| 28-Oct to 01-Nov Campagnaro Unknown injury |
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| 31-Oct to 02-Nov Cannavaro, P Champions League yellow card ban (1 match) |
| M.4 | 02-Nov | away | Bayern | | 3-2 | 3-4-2-1 | In:Fern'z, Džemaili, Out:Cannavaro, Gargano, |
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| 18-Nov to 20-Nov Santana red card ban (1 match) |
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| 21-Nov to 23-Nov Zúñiga, C Champions League red card ban (1 match) |
| M.5 | 22-Nov | | Man.City | | 2-1 | 3-4-2-1 | In:Cannavaro, Gargano, Dossena, Out:Fern'z, Džemaili, Zuni', , |
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| December 2011 |
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| M.6 | 07-Dec | away | Villarreal | | 0-2 | 3-4-2-1 | In:Zuni', , Out:Dossena, |
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| February 2012 |
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 17-Dec to 17-Dec Vargas, E to join Napoli on January. US$17.5 millions transfer |
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| 19-Dec to 20-Jan Lavezzi right thigh rectus femoris muscle strain |
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| 30-Jan to 02-Feb Lavezzi 4th yellow card ban (1 match) |
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| 10-Feb to 13-Feb Cannavaro, P 4th yellow card ban (1 match) |
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| 14-Feb to 27-Feb Vargas, E ankle sprain |
| M.7 | 21-Feb | | Chelsea | | 3-1 | 3-4-2-1 | *** Repeat 11 *** |
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| March 2012 |
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| 02-Mar to 04-Mar Aronica red card ban (1 match) |
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| 05-Mar to 14-Mar Grava right rectus femoris muscle strain |
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| 05-Mar to 14-Mar Britos bruised foot |
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| 08-Mar to 11-Mar Džemaili 4th yellow card ban (1 match) |
| M.8 | 14-Mar | away | Chelsea | | 4-1 | 3-4-2-1 | *** Repeat 11 *** |
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| 22-Mar to 29-Mar Maggio left thigh biceps femoris muscle pain |
| April 2012 |
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| 02-Apr to 18-Apr Maggio flexor |
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| 04-Apr to 06-Apr Dossena calf |
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| 06-Apr to 12-Apr Zúñiga, C Federal Judge ban for violent behaviour (2 matches) |
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| 06-Apr to 07-Apr Gargano 4th yellow card ban (1 match) |
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| 07-Apr to 25-Apr Rosati left thigh biceps femoris muscle strain |
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| 09-Apr to 12-Apr Britos 4th yellow card ban (1 match) |
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| 09-Apr to 12-Apr Cannavaro, P 8th yellow card ban (1 match) |
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| 19-Apr to 25-Apr Lavezzi left thigh rectus femoris muscle pain |
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| 20-Apr to 25-Apr Pandev Federal Judge ban for unsporting behaviour (2 matches) |
| May 2012 |
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| 26-Apr to 13-May Campagnaro right thigh flexor muscle strain |
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| 30-Apr to 02-May Džemaili 8th yellow card ban (1 match) |
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| 30-Apr to 02-May Santana 4th yellow card ban (1 match) |
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| 04-May to 06-May Fernández, F 4th yellow card ban (1 match) |
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| 12-May to 14-May Džemaili FJ ban for unsporting behaviour (2 matches), 9th yellow card |
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| 12-May to 14-May Aronica 4th yellow card ban (1 match) |
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| 12-May to 14-May Cavani 4th yellow card ban (1 match) |
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| 12-May to 14-May Mascara 4th yellow card ban (1 match) |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |