| Lineups found Starting lineup changes since last game |
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| August 2011 |
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| Coach Mazzarri since 06-Oct-09 |
| November 2011 |
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 22-Aug to 22-Nov Britos right metatharsal fracture |
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| 03-Sep to 21-Sep Donadel rectus femoris muscle strain |
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 08-Sep to 11-Sep Gargano 8th yellow card ban from Serie A 2010/2011 season |
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| 19-Sep to 22-Sep Campagnaro Rested |
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| 19-Sep to 22-Sep Dossena Rested |
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| 19-Sep to 22-Sep Lavezzi Rested |
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| 21-Sep to 15-Dec Donadel Thigh injury |
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| 22-Sep to 30-Sep Maggio right thigh muscle pain |
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| 22-Sep to 14-Oct Džemaili Ankle injury |
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| 28-Sep to 06-Oct Cavani right ankle sprain |
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| 05-Oct to 31-Oct Pandev left leg biceps femoris muscle strain |
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| 23-Oct to 16-Nov Gargano left adductor muscle strain |
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| 28-Oct to 01-Nov Campagnaro Unknown injury |
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| 31-Oct to 02-Nov Cannavaro, P Champions League yellow card ban (1 match) |
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| 21-Nov to 23-Nov Zúñiga, C Champions League red card ban (1 match) |
| December 2011 |
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| January 2012 |
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 17-Dec to 17-Dec Vargas, E to join Napoli on January. US$17.5 millions transfer |
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| 19-Dec to 20-Jan Lavezzi right thigh rectus femoris muscle strain |
| M.5 | 12-Jan | | Cesena | | 2-1 | 3-4-2-1 | |
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| M.6 | 25-Jan | | Inter | | 2-0 | 3-4-2-1 | In:D Sanctis, Camp'ro, Aronica, Maggio, Gargano, Lavezzi, Out:Rosati, Fern'z, Britos, Džemaili, Dossena, Vargas, |
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| February 2012 |
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| 30-Jan to 02-Feb Lavezzi 4th yellow card ban (1 match) |
| M.7 | 09-Feb | away | Siena | | 2-1 | 3-4-2-1 | In:Džemaili, Pandev, Out:Inler, Lavezzi, |
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| March 2012 |
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| 10-Feb to 13-Feb Cannavaro, P 4th yellow card ban (1 match) |
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| 14-Feb to 27-Feb Vargas, E ankle sprain |
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| 02-Mar to 04-Mar Aronica red card ban (1 match) |
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| 05-Mar to 14-Mar Grava right rectus femoris muscle strain |
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| 05-Mar to 14-Mar Britos bruised foot |
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| 08-Mar to 11-Mar Džemaili 4th yellow card ban (1 match) |
| M.8 | 21-Mar | | Siena | | 2-0 | 3-4-2-1 | In:Inler, Lavezzi, Out:Džemaili, Pandev, |
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| May 2012 |
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| 22-Mar to 29-Mar Maggio left thigh biceps femoris muscle pain |
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| 02-Apr to 18-Apr Maggio flexor |
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| 04-Apr to 06-Apr Dossena calf |
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| 06-Apr to 12-Apr Zúñiga, C Federal Judge ban for violent behaviour (2 matches) |
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| 06-Apr to 07-Apr Gargano 4th yellow card ban (1 match) |
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| 07-Apr to 25-Apr Rosati left thigh biceps femoris muscle strain |
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| 09-Apr to 12-Apr Britos 4th yellow card ban (1 match) |
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| 09-Apr to 12-Apr Cannavaro, P 8th yellow card ban (1 match) |
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| 19-Apr to 25-Apr Lavezzi left thigh rectus femoris muscle pain |
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| 20-Apr to 25-Apr Pandev Federal Judge ban for unsporting behaviour (2 matches) |
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| 26-Apr to 13-May Campagnaro right thigh flexor muscle strain |
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| 30-Apr to 02-May Džemaili 8th yellow card ban (1 match) |
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| 04-May to 06-May Fernández, F 4th yellow card ban (1 match) |
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| 12-May to 14-May Džemaili FJ ban for unsporting behaviour (2 matches), 9th yellow card |
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| 12-May to 14-May Aronica 4th yellow card ban (1 match) |
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| 12-May to 14-May Cavani 4th yellow card ban (1 match) |
| M.9 | 20-May | away | Juventus | | 0-2 | 3-4-2-1 | In:Džemaili, Out:Gargano, |
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| Color References: GK, DF, DM, MF, FW , Unknown Pos |