| Lineups found Starting lineup changes since last game |
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| October 2021 |
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| Coach Farke since 25-May-17 |
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 07-Aug to 13-Aug Rashica Covid-19 |
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| 08-Aug to 13-Aug Rupp Ankle Injury |
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| 08-Aug to 13-Aug Hanley Covid-19 |
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| 08-Aug to 16-Oct Płacheta Covid-19 |
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| 25-Aug to 10-Sep Tzolis Calf Injury |
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| 29-Aug to 16-Jan Zimmermann, C Ankle Injury |
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| 29-Aug to 17-Sep Giannoulis, D (1995) Back Injury |
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| 29-Aug to 17-Sep Sargent Thigh Injury |
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| 12-Sep to 18-Sep Sørensen, Jakob Thigh Injury |
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| 12-Sep to 17-Sep Lees-Melou Illness |
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| 25-Sep to 01-Oct Normann, M Thigh Injury |
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| 03-Oct to 15-Oct Normann, M Abdominal Injury |
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| Coach Neilson since 18-Aug-21 |
| November 2021 |
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 22-Oct to 23-Oct Gilmour, B Unable to Face Parent Club |
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| 30-Oct to 31-Oct Gibson, Ben Red Card Ban |
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| Coach Smith, D since 15-Nov-21 |
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| Coach Shakespeare since 15-Nov-21 |
| December 2021 |
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| 13-Dec to 24-Feb Rupp Thigh Injury |
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| 13-Dec to 05-Feb Normann, M Groin Injury |
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| 13-Dec to 02-Jan Hanley Shoulder Injury |
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| 13-Dec to 02-Jan Rashica Groin Injury |
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| 13-Dec to 15-Dec Tzolis Illness |
| January 2022 |
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| 25-Dec to 22-Jan Krul Knee Injury |
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| 27-Dec to 02-Jan Pukki Illness |
| M.7 | 09-Jan | away | Charlton | | 0-1 | 4-2-3-1 | |
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| February 2022 |
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| 11-Jan to 05-Feb Gilmour, B Ankle Injury |
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| 16-Jan to 23-Feb Krul Shoulder Injury |
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| 21-Jan to 26-Feb Sørensen, Jakob Knee Injury |
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| 22-Jan to 10-Feb Sargent Illness |
| M.8 | 05-Feb | away | Wolves | | 0-1 | 4-3-3 | In:McGovern, Gibson, Williams, Gilmour, Płacheta, Idah, Rashica, Out:Krul, Kabak, Gian'is, Sore'n, Dowell, Tzolis, Sargent, |
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| March 2022 |
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| 08-Feb to 13-Feb Kabak, O Illness |
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| 18-Feb to 23-May Idah Knee Injury |
| M.9 | 02-Mar | away | Liverpool | | 2-1 | 4-3-3 | In:Krul, Zimm'nn, Gian'is, Rupp, Normann, Pukki, Out:McGovern, Hanley, Williams, Gilmour, McLean, Idah, |
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| 04-Mar to 06-Mar Kabak, O Shoulder Injury |
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| 09-Mar to 11-Mar Gilmour, B Loan agreement |
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| 12-Mar to 14-Mar Byram Lacking Match Fitness |
| April 2022 |
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| 01-Apr to 23-May Kabak, O Thigh Injury |
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| 01-Apr to 11-Apr Aarons, M Thigh Injury |
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| 01-Apr to 23-May Sargent Ankle Injury |
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| 09-Apr to 11-Apr Płacheta Ankle Injury |
| May 2022 |
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| 18-Apr to 28-Apr Rupp Knee Injury |
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| 29-Apr to 21-May Zimmermann, C Hip Injury |
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| 10-May to 23-May McLean Toe Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |