| Lineups found Starting lineup changes since last game |
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| July 2021 |
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| Coach Farke since 25-May-17 |
| August 2021 |
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 07-Aug to 13-Aug Rashica Covid-19 |
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| 08-Aug to 13-Aug Cantwell, T Ankle Injury |
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| 08-Aug to 13-Aug Rupp Ankle Injury |
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| 08-Aug to 13-Aug Hanley Covid-19 |
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| 08-Aug to 13-Aug Mumba Covid-19 |
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| Coach Neilson since 18-Aug-21 |
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| 13-Aug to 21-Aug Omobamidele Knock |
| M.2 | 24-Aug | | Bournemth | | 6-0 | 4-4-2 | |
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| 25-Aug to 10-Sep Tzolis Calf Injury |
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| 25-Aug to 18-Sep Mumba Knee Injury |
| September 2021 |
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| 29-Aug to 16-Jan Zimmermann, C Ankle Injury |
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| 29-Aug to 17-Sep Giannoulis, D (1995) Back Injury |
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| 29-Aug to 17-Sep Sargent Thigh Injury |
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| 12-Sep to 18-Sep Sørensen, Jakob Thigh Injury |
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| 12-Sep to 17-Sep Lees-Melou Illness |
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| 19-Sep to 19-Nov Cantwell, T Achilles Injury |
| M.3 | 21-Sep | | Liverpool | | 0-3 | 3-1-4-2 | In:Hanley, Gibson, Gilmour, Lees'ou, Gian'is, Idah, Out:Zimm'nn, Williams, Sore'n, McLean, Dowell, Sargent, |
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| October 2021 |
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 22-Oct to 23-Oct Gilmour, B Unable to Face Parent Club |
| December 2021 |
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| Coach Smith, D since 15-Nov-21 |
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| Coach Shakespeare since 15-Nov-21 |
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| 30-Oct to 31-Oct Gibson, Ben Red Card Ban |
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| 13-Dec to 24-Feb Rupp Thigh Injury |
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| 13-Dec to 02-Jan Hanley Shoulder Injury |
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| 13-Dec to 02-Jan Rashica Groin Injury |
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| 13-Dec to 15-Dec Tzolis Illness |
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| 13-Dec to 23-May Omobamidele Lower Back Injury |
| January 2022 |
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| 25-Dec to 22-Jan Krul Knee Injury |
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| 27-Dec to 02-Jan Pukki Illness |
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| 11-Jan to 13-Jan Cantwell, T Illness |
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| 11-Jan to 05-Feb Gilmour, B Ankle Injury |
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| 16-Jan to 23-Feb Krul Shoulder Injury |
| February 2022 |
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| 21-Jan to 26-Feb Sørensen, Jakob Knee Injury |
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| 22-Jan to 10-Feb Sargent Illness |
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| 18-Feb to 23-May Idah Knee Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |