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Orlando City Substitutions at Major League Soccer 2021
| Most In | | Most Out | | Michel, B | 12 times | 26 minutes avg | | van de Water | 9 | 15 | | Rosell, O | 7 | 13 | | Schlegel, R | 7 | 21 | | Más, E | 7 | 16 | | Akindele | 7 | 17 | | Perea, A | 6 | 30 | | Mueller | 6 | 27 | | Moutinho, J | 6 | 28 | | DeZart | 6 | 6 | | Nani | 5 | 23 | | Smith, Kyle | 4 | 6 | | Alvarado, Alexander | 3 | 5 | | Aguilera Jr | 3 | 31 | | Alexandre Pato | 3 | 11 | | Matheus Aiás | 2 | 6 | | Dike, D | 2 | 24 | | Pereyra, M | 2 | 24 | | Ruan, GT | 2 | 40 | | Jansson, Robin | 1 | 39 | | Halliday, Michael (2003) | 1 | 44 | | Antonio Carlos, Capocasali | 1 | 17 | | Loera, D | 1 | 21 | | Méndez, Sebas | 1 | 20 |
| | | Mueller | 12 times | 75 minutes avg | | Pereyra, M | 11 | 75 | | Junior Urso | 10 | 79 | | van de Water | 9 | 65 | | Méndez, Sebas | 9 | 68 | | Michel, B | 8 | 70 | | Ruan, GT | 7 | 78 | | Akindele | 5 | 65 | | Rosell, O | 5 | 73 | | Moutinho, J | 4 | 57 | | Smith, Kyle | 4 | 63 | | DeZart | 4 | 62 | | Nani | 3 | 65 | | Halliday, Michael (2003) | 3 | 76 | | Más, E | 3 | 67 | | Antonio Carlos, Capocasali | 2 | 30 | | Dike, D | 2 | 72 | | Perea, A | 2 | 85 | | Alvarado, Alexander | 1 | 66 |
| | 35 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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