| Lineups found Starting lineup changes since last game |
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| August 2010 |
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| Coach Ranieri since 01-Sep-09 |
| October 2010 |
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 26-Aug to 14-Sep Adriano right thigh adductor muscle strain |
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| 07-Sep to 24-Sep Riise head collision wth Espen Ruud during Norway training session |
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| 12-Sep to 24-Sep Castellini left biceps femoris muscle strain |
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 17-Sep to 23-Sep Burdisso red card ban + FJ ban for dangerous play (2 matches) |
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| 23-Sep to 26-Sep Mexès red card + FJ ban for insulting the referee (1 of 3 matches) |
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| 23-Sep to 22-Oct Júlio Sérgio right ankle strain, talofibular ligament involved |
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| 30-Sep to 03-Oct Mexès red card + FJ ban for insulting the ref (2 matches, later 1) |
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| 30-Sep to 31-Oct Adriano left ankle straining trauma |
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| 01-Oct to 03-Oct Perrotta 4th yellow card ban (1 match) |
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| 11-Oct to 24-Oct De Rossi left thigh fatigue |
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| 25-Oct to 01-Dec Taddei right gastrocnemius muscle injury |
| November 2010 |
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| 05-Nov to 07-Nov Totti red card ban (1 match) |
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| 08-Nov to 11-Nov Cassetti 4th yellow card ban (1 match) |
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| 13-Nov to 23-Nov Perrotta right knee straining trauma |
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| 25-Nov to 28-Nov Burdisso red card ban (1 match) |
| December 2010 |
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| 02-Dec to 07-Feb Pizarro, D knee injury |
| January 2011 |
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| 14-Jan to 16-Jan Júlio Sérgio red card ban (1 match) |
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| 17-Jan to 20-Jan Totti Coppa Italia FJ ban from 2009-10 season (4 matches) |
| M.5 | 19-Jan | | Lazio | | 2-1 | 4-3-1-2 | |
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| 20-Jan to 01-Apr Adriano dislocated shoulder |
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| 21-Jan to 23-Jan Burdisso 4th yellow card ban (1 match) |
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| 24-Jan to 27-Jan Totti Coppa Italia FJ ban from 2009-10 season (4 matches) |
| M.6 | 27-Jan | away | Juventus | | 0-2 | 4-3-1-2 | In:Cassetti, Perrotta, Ménez, Vučinić, Out:Juan, Greco, Adriano, Borriello, |
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| April 2011 |
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| Coach Montella since 21-Feb-11 |
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| 04-Feb to 13-Feb Mexès Federal Judge ban for insulting the referee (2 matches) |
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| 11-Feb to 13-Feb Burdisso red card ban (1 match) |
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| 18-Feb to 20-Feb Rosi Federal Judge ban for unsporting conduct (1st of 3 matches) |
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| 18-Feb to 20-Feb Cassetti 8th yellow card ban (1 match) |
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| 18-Feb to 20-Feb De Rossi 4th yellow card ban (1 match) |
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| 25-Feb to 28-Feb Greco, L 4th yellow card ban (1 match) |
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| 25-Feb to 28-Feb Mexès 4th yellow card ban (1 match) |
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| 25-Feb to 06-Mar Rosi Federal Judge ban for unsporting conduct (2 of 3 matches) |
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| 03-Mar to 06-Mar Totti 4th yellow card ban (1 match) |
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| 07-Mar to 10-Mar Cassetti Champions League yellow card ban (1 match) |
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| 07-Mar to 10-Mar Ménez Champions League yellow card ban (1 match) |
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| 10-Mar to 13-Mar Brighi 4th yellow card ban (1 match) |
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| 18-Mar to 20-Mar Vučinić 4th yellow card ban (1 match) |
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| 18-Mar to 30-Apr Júlio Sérgio right ankle |
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| 15-Apr to 17-Apr Juan 4th yellow card ban (1 match) |
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| 18-Apr to 20-Apr Totti Coppa Italia FJ ban from 2009-10 season (4 matches) |
| M.7 | 19-Apr | | Inter | | 0-1 | 4-2-3-1 | In:Doni, Juan, Pizarro, Taddei, Borriello, Out:J Sérgio, Mexès, Brighi, Simplicio, Ménez, |
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| May 2011 |
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| 06-May to 09-May De Rossi Federal Judge ban for violent behaviour (1st of 3 matches) |
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| 06-May to 09-May Perrotta Federal Judge ban for violent behaviour (1st of 3 matches) |
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 09-May to 09-May Mexès to join AC Milan in July |
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| 09-May to 11-May Totti Coppa Italia FJ ban from 2009-10 season (4 matches) |
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| 09-May to 11-May Taddei Coppa Italia yellow card ban (1 match) |
| M.8 | 11-May | away | Inter | | 1-1 | 4-2-3-1 | In:Simplicio, Ménez, Out:Taddei, Vučinić, |
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| Color References: GK, DF, DM, MF, FW , Unknown Pos |