| Lineups found Starting lineup changes since last game |
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| July 2022 |
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| Coach Mourinho since 01-Jul-21 |
| August 2022 |
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 05-Aug to 14-Sep Solbakken, O Injury |
| October 2022 |
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| 21-Aug to 05-Feb Wijnaldum Broken shinbone |
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| 26-Aug to 11-Sep Zaniolo Shoulder Injury |
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| 03-Sep to 30-Sep El Shaarawy Injury |
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| 03-Sep to 19-Sep Kumbulla Injury |
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| 07-Sep to 09-Sep Abraham, Tammy Shoulder Injury |
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| 11-Sep to 17-Sep Zalewski, N Muscle Injury |
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| 08-Oct to 28-Oct Çelik, Mehmet Knee Injury |
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| 12-Oct to 12-Nov Dybala Muscle Injury |
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 12-Oct to 14-Oct Zaniolo Red Card |
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| 16-Oct to 21-Oct Kumbulla Injury |
| January 2023 |
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| 02-Nov to 04-Nov Mancini, G Yellow Cards |
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| 02-Nov to 14-Nov Spinazzola Injury |
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| 08-Nov to 12-Nov Pellegrini, L Thigh Injury |
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 23-Nov to 23-Nov Solbakken, O joining Roma in January 2023 |
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| 03-Jan to 05-Jan Belotti, A Muscle Injury |
| M.4 | 12-Jan | | Genoa | | 1-0 | 3-4-1-2 | |
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| 14-Jan to 16-Jan Ibañez, Roger Yellow Cards |
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| 21-Jan to 30-Jan Zaniolo Injury |
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| 28-Jan to 30-Jan Çelik, Mehmet Yellow Cards |
| February 2023 |
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| M.5 | 01-Feb | | Cremonese | | 1-2 | 3-4-2-1 | In:Çelik, Cristante, Tahi'c, Volpato, Belotti, Out:Zalewski, Bove, E, Matić, Zaniolo, Abraham, |
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| April 2023 |
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| 03-Feb to 15-Feb Spinazzola Injury |
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| 18-Feb to 22-Feb Dybala Thigh Injury |
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| 27-Feb to 01-Mar Smalling Yellow Cards |
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| 03-Mar to 10-Mar Viña, M Knee Injury |
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| 08-Mar to 10-Mar Ibañez, Roger Yellow Cards |
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| 08-Mar to 18-Mar Solbakken, O Muscle Injury |
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| 11-Mar to 13-Mar Cristante, B Yellow Cards |
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| 11-Mar to 14-Mar Pellegrini, L Injury |
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| 11-Mar to 17-Mar Belotti, A Injury |
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| 15-Mar to 18-Mar Llorente, Diego (1993) Muscle Injury |
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| 18-Mar to 20-Mar Kumbulla Red Card |
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| 01-Apr to 03-Apr Cristante, B Red Card |
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| 01-Apr to 03-Apr Kumbulla Red Card |
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| 01-Apr to 03-Apr Mancini, G Yellow Cards |
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| 01-Apr to 03-Apr Ibañez, Roger Red Card |
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| 12-Apr to 14-Apr Solbakken, O Shoulder Injury |
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| 15-Apr to 18-Apr Dybala Muscle Injury |
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| 23-Apr to 04-May Wijnaldum Injury |
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| 23-Apr to 17-May Smalling Injury |
| May 2023 |
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| 28-Apr to 21-May Llorente, Diego (1993) Muscle Injury |
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| 02-May to 04-May Matić, N Yellow Cards |
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| 02-May to 04-May Belotti, A Broken rib |
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| 05-May to 07-May Çelik, Mehmet Red Card |
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| 13-May to 17-May El Shaarawy Injury |
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| 19-May to 21-May Zaniolo Red Card |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |