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Santos Laguna Substitutions at Apertura 2021
| Most In | | Most Out | | Ocejo | 10 times | 20 minutes avg | | Jeraldino | 9 | 15 | | Carrillo, J | 8 | 25 | | Lozano | 7 | 21 | | Ibargüen, A | 4 | 25 | | Cervantes, Alan | 3 | 22 | | Andrade, David (1993) | 2 | 44 | | Valdés, Diego | 2 | 37 | | Gorriarán | 2 | 37 | | Otero, Juan | 2 | 34 | | Orrantía | 2 | 24 | | Rodríguez, H | 2 | 25 | | Games | 1 | 15 | | Isijara | 1 | 9 | | Prieto, RdJ | 1 | 13 | | da Cruz, A | 1 | 16 | | Govea, I | 1 | 31 | | Preciado, Ayrton | 1 | 21 | | Ávila, José | 1 | 10 |
| | | Aguirre, E | 10 times | 74 minutes avg | | Preciado, Ayrton | 7 | 66 | | Carrillo, J | 6 | 66 | | Otero, Juan | 5 | 67 | | Cervantes, Alan | 4 | 67 | | Lozano | 4 | 68 | | Ocejo | 3 | 64 | | Isijara | 3 | 65 | | Prieto, RdJ | 3 | 61 | | Valdés, Diego | 3 | 79 | | Orrantía | 2 | 80 | | Govea, I | 2 | 68 | | da Cruz, A | 2 | 62 | | Gorriarán | 1 | 69 | | Campos, Omar (2002) | 1 | 41 | | Ávila, José | 1 | 46 | | Rodríguez, H | 1 | 46 | | Díaz, JA | 1 | 60 | | Ibargüen, A | 1 | 73 |
| | 20 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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