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Seattle Sounders Substitutions at Major League Soccer 2021
| Most In | | Most Out | | Leyva, D | 11 times | 16 minutes avg | | Rowe, K | 10 | 22 | | Medranda | 9 | 22 | | Montero, F | 7 | 15 | | Bruin | 7 | 10 | | Léo Chú | 7 | 20 | | Smith, Brad | 6 | 22 | | O'Neill, Shane (1993) | 5 | 35 | | Atencio | 5 | 10 | | Benezet | 5 | 23 | | Gómez Andrade | 4 | 17 | | Dobbelaere | 4 | 8 | | Delem | 3 | 9 | | João Paulo, M | 3 | 39 | | Lodeiro | 3 | 23 | | Tolo, Nouhou | 3 | 28 | | Baker-Whiting | 2 | 28 | | Morris, Jordan | 2 | 38 | | Arreaga | 1 | 9 | | Adeniran, S | 1 | 5 | | Villanueva, Alex | 1 | 7 | | Roldan, Alex | 1 | 2 | | Cissoko, A | 1 | 0 | | Ruidíaz | 1 | 45 |
| | | Smith, Brad | 17 times | 73 minutes avg | | Medranda | 12 | 69 | | Rowe, K | 11 | 77 | | João Paulo, M | 8 | 79 | | Cissoko, A | 7 | 70 | | Atencio | 7 | 63 | | O'Neill, Shane (1993) | 6 | 76 | | Montero, F | 6 | 70 | | Bruin | 5 | 70 | | Roldan, Alex | 5 | 74 | | Arreaga | 4 | 79 | | Leyva, D | 3 | 76 | | Benezet | 3 | 71 | | Tolo, Nouhou | 2 | 57 | | Ruidíaz | 2 | 53 | | Delem | 1 | 9 | | Dobbelaere | 1 | 46 | | Vargas, Obed | 1 | 77 | | Roldan, C | 1 | 46 |
| | 35 games found - Color References: GK, DF, DM, MF, FW , Unknown Pos |
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