| Lineups found Starting lineup changes since last game |
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| October 2021 |
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| Coach Nuno Espírito Santo since 30-Jun-21 |
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 07-Aug to 14-Aug Romero, Cristian (1998) Knee Injury |
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| 08-Aug to 18-Aug Sessegnon, R Hamstring Strain |
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| 08-Aug to 19-Aug Kane Knock |
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| 08-Aug to 10-Sep Ndombèlé Knock |
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| 27-Aug to 28-Aug Son, Heung-min Thigh Injury |
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| 29-Aug to 11-Sep Bergwijn Ankle Injury |
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| 30-Aug to 20-Nov Sessegnon, R Knock |
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| 30-Aug to 18-Sep Son, Heung-min Tight Calf Muscles |
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| 30-Aug to 10-Sep Skipp Groin Injury |
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 06-Sep to 18-Sep Romero, Cristian (1998) Quarantine Regulations |
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| 06-Sep to 18-Sep Lo Celso Quarantine Regulations |
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| 06-Sep to 18-Sep Sánchez, Davinson Quarantine Regulations |
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| 11-Sep to 18-Sep Dier Thigh Injury |
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| 16-Sep to 16-Oct Bergwijn Ankle Injury |
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| 17-Sep to 19-Sep Tanganga Domestic Red Card Ban |
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| 17-Sep to 25-Sep Lucas Moura Ankle Injury |
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| 27-Sep to 16-Oct Davies, Ben (1993) Illness |
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| 10-Oct to 26-Oct Doherty, Matthew (1992) Knock |
| November 2021 |
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| Coach Conte since 02-Nov-21 |
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| Coach Stellini since 02-Nov-21 |
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| 27-Oct to 20-Nov Bryan Gil Hamstring Injury |
| December 2021 |
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| January 2022 |
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| 18-Dec to 24-Jan Romero, Cristian (1998) Thigh Injury |
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| 18-Dec to 29-Dec Scarlett, D Illness |
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| 18-Dec to 20-Dec Bryan Gil Illness |
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| 25-Dec to 02-Jan Sessegnon, R Thigh Injury |
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| 27-Dec to 29-Dec Lo Celso Injury |
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| 31-Dec to 02-Jan Bergwijn Calf Injury |
| M.7 | 09-Jan | | Morecambe | | 3-1 | 5-3-2 | |
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| February 2022 |
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| 15-Jan to 17-Jan Reguilón Muscle Injury |
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| 15-Jan to 20-Jan Dier Illness |
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| 15-Jan to 24-Jan Son, Heung-min Muscle Injury |
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| 24-Jan to 14-Feb Dier Thigh Injury |
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| 24-Jan to 23-May Skipp Groin Strain |
| M.8 | 05-Feb | | Brighton | | 3-1 | 3-4-3 | In:Lloris, Sánchez, Romero, E Royal, Hojb'g, Reguilón, L Moura, Kane, Son, Out:Gollini, Doherty, Tanganga, Rodon, Sessegnon, L Celso, Ndom'le, B Gil, Alli, |
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| March 2022 |
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| 15-Feb to 21-Feb Reguilón Illness |
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| 25-Feb to 27-Feb Bentancur, R Leg Injury |
| M.9 | 01-Mar | away | Middlsbro | | 1-0 | 3-4-2-1 | In:Dier, Doherty, Sessegnon, Kulu'ki, Out:Sánchez, E Royal, Reguilón, L Moura, |
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| 03-Mar to 05-Mar Ndombèlé Injury |
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| 11-Mar to 08-Apr Sessegnon, R Thigh Injury |
| April 2022 |
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| 15-Apr to 23-May Doherty, Matthew (1992) Knee Injury |
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| 16-Apr to 24-Apr Ndombèlé Injury |
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| 17-Apr to 23-May Reguilón Groin Injury |
| May 2022 |
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| 14-May to 23-May Romero, Cristian (1998) Hip Injury |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |