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| 11-May-23 19:00
Estadio Ka’arendy
Ref:Benítez, D Lm 1:Cañete Lm 2:Weiler |
| General Caballero JLM
González, Clementino 54' González, Clementino 71' Arce, Sebastián 92'
| 3 - 0 | Guaireña FC
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| 12-May-23 17:30
Estadio Defensores del Chaco
Ref:Quintana Lm 1:Aranda Lm 2:Miranda, G |
| Sportivo Ameliano
Samudio, A 1' Doldán, J 70'
| 2 - 1 | Tacuary
78' Valdez, I
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| 12-May-23 20:00
Estadio Tigo La Huerta
Ref:López, D Lm 1:Cardozo Lm 2:Villagra |
| Libertad
Sanabria, L (1999) 33' Bareiro, A 57'
| 2 - 1 | Trinidense
69' Riveros, M
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| 13-May-23 17:00
Estadio General Pablo Rojas
Ref:Benitez, C Lm 1:Candia Lm 2:Medina, H |
| Cerro Porteño
Aquino, C 14' Espínola, Alberto 36'
| 2 - 2 | Olimpia
22' Fernández, H 93' Quintana, H
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| 14-May-23 17:00
Rogelio Livieres
Ref:López, J Lm 1:Onieva Lm 2:Gaona |
| Guaraní
Santander, Federico 71' Moreira, Estivel 84'
| 2 - 2 | Nacional
67' Aguilar, GÁ 78' Ocampos, C
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| 14-May-23 19:30
Luis Alfonso Giagni
Ref:Benitez, J Lm 1:Cuevas, J Lm 2:Saldivar, M |
| Resistencia
Villalba, Alexis 95'
| 1 - 1 | Sportivo Luqueño
21' Pérez, Marcelo (2001)
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