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| 18-Mar-23 18:00
Parque del Guairá
Ref:Juliadoza
Lm 1:Onieva
Lm 2:Miranda, G
|
 | Guaireña FC
| 0 - 1 | Sportivo Ameliano
 26' Torales, S
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| 18-Mar-23 20:30
Estadio Defensores del Chaco
Ref:Méndez, J
Lm 1:Aquino
Lm 2:Mercado
|
 | Nacional
Núñez, Claudio 75' 
| 0 - 1 | Sportivo Luqueño
55' Pérez, Marcelo (2001)
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| 19-Mar-23 18:00
Manuel Ferreira
Ref:Benitez, C
Lm 1:Britos
Lm 2:Villagra
|
 | Olimpia
Montenegro, B 37'
Bruera, F 95'
| 2 - 1 | Libertad
 24' Villalba, H
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| 19-Mar-23 20:30
Martín Torres
Ref:Benitez, J
Lm 1:Saldivar, M
Lm 2:Gaona
|
 | Trinidense
Delvalle, P 9'
| 1 - 1 | Guaraní
55' Camacho, N
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| 20-Mar-23 18:00
Estadio Ka’arendy
Ref:Ojeda, D
Lm 1:Cardozo
Lm 2:Arzamendia
|
 | General Caballero JLM
Sanguina 18'
Báez, C 34'
| 2 - 3 | Cerro Porteño
39' Samudio, B
60' Churín
69' Carrizo, F
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| 20-Mar-23 20:30
Luis Alfonso Giagni
Ref:Quintana
Lm 1:Candia
Lm 2:Medina, H
|
 | Tacuary
Cabral, L 33'
Valdez, I 53'
| 2 - 0 | Resistencia
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